The Effect Of Homeobox Gene On Pathogenesis Of Hemangioma In Vitro

ObjectiveInfantile hemangioma (often abbreviated as hemangioma) is the most common benign tumor in infancy characterized by rapid growth in early life and subsequent spontaneous regression in the following years. Though most hemangiomas end in automatic involution, the early rapid growth of some hemangiomas with special location may compromise the function of important organs, or are life-threatening, or bring cosmetic problem and warrant medical intervention. The causative pathogenic event responsible for the abnormal endothelial proliferation and involution remains elusive.Homeobox genes are a family of transcription factors with a highly conserved 61-amino-acid DNA-binding domain known as the homeodomain, containing a helix-turn-helix motif, that regulate cell proliferation, differentiation, and migration in many cell types in diverse organisms. Homeobox genes play a critical role in pattern formation in the...