Application Of Fiber-Optic Sensing And Molecular Imprinted Polymer Fluorescence Sensing Membrane In Amiodarone Assay

Amiodarone hydrochloride is a hydrophobic drug, so its internal absorption is affected by preparation factors greatly. Because of comparatively large individual variation of its absorption and elimination after oral administration or intravenous injection, it is necessary to develop a fast and on line method for amiodarone determination. Although present assays such as HPTLC and HPLC are very sensitive and accurate for amiodarone blood samples, they have disadvantages of sampling analysis. Therefore, it has significant importance to develop and establish an in-situ monitoring technique or method for amiodarone. In recent decades, molecular imprinting technique have found a multitude uses in such fields as chromatographic separation, antibody imitating, solid phase extraction, biosensors, catalysis, pharmaceutical analysis and mimic enzymes. Being very sensitive, high selective, fast and convenient, fluorescence quenching method has great significance in analysis of non-fluorescent or very low fluorescent analytes despite organic or inorganic compounds.Novel method which can monitor the dissolution rate of amiodarone hydrochloride using fiber-optic dissolution testing (FODT) system was established and compared with Ch.P 2005. The common ends of the optic...