Diffusion-weighted Imaging And Perfusion-weighted Imaging In Diagnosing Early Cerebral Infarction

Purpose of the study:To study the roles of isotropic diffusion weighted imaging(DWI) and perfusion weighted imaging(PWI) in diagnosing early cerebral infarction(the time after onset of stroke: ≤24 hours), and in monitoring the development of cerebral ischemic penumbra. The major investigations including: evaluate the differences in cerebral perfusion seen on mean transit time(MTT) and cerebral blood volume(CBV) maps and to assess the subsequent prognostic value of the MTT-DWI and CBV-DWI mismatch in the first day of infarction on lesion enlargement and in predicting final infarct size; evaluate the roles of rADC, rMTT and rrCBV in determining the ischemic penumbra; investigate the roles of DWI and PWI with the help of the techniques of 2D hydrogen proton magnetic resonance spectroscopy imaging(2D ~1H-MRSI) and MR angiography(MRA), in diagnosing early cerebral infarction and in the endovascular stent-assisted angioplasty treatment for patients with acute stroke. Material and Methods:42 cases (6 hyperacute,36 acute) were studied, including 22 male and 20 female, ages from 36 to 80 years old and mean 54.60 years old. 88 work-ups of 42 patients were imaged with conventional MRI and single-shot echo-planar isotropic diffusion weighted imaging. Among the patients, 35 PWI and 76 MRA were performed successfully in 30 persons(Only one patient received...