Expression And Change Of Calbindin-d28k In Human Female Reproductive System

BackgroundCalbindin-d28k (CaBP-d28k) , a kind of calcium-binding protein, belongs to a kind of eucaryotic proteins and 28 kd vitamin D-dependent calcium-binding protein. CaBP-d28k contains EF hand motifs, which have high affinity for Ca²⁺ ions to a specific helix-loop-helix structure. CaBP-d28k is thought to buffer intracellular calcium levels and plays several important physiological roles. Previous investigations to animals demonstrated that CaBP-d28k played important roles in the events of female reproduction. But to human, there were no fully studies on the relation of female reproduction and CaBP-d28k. Now, the relationship between CaBP-d28k and the physiological and pathological function of female reproduction was still unknown. The presence and localization of CaBP-d28k has not been studied in human fallopian tube and ovary. Studies about CaBP-d28k in human uterus were also rare. Previous studies showed that CaBP-d28k was concerned with the process of implantation. But, whether the etiology of some female infertility ralated the CaBP-d28k was unknown. The expression of CaBP-d28k in human pathological female reproduction, the role of CaBP-d28k in human...