| This subject used modern scientific technology to study Jiangzhijianfei Capsules based on the theory of TCM, including pharmacy, pharmacodynamics, toxicology.The results of pharmacy show that the extraction process is stable and reasonable, which was optimized by taking pericarpium citri reticulatae volatile oil rate and content of puerarin, emodin and monoammoniun glycyrrhizinate as the index by orthogonal design. In addition , the relate quality control standard was formulated for Jiangzhijianfei Capsules by determining the content of astragaloside of it by HPLC-ELSD, and the above method is proved to be convenient with high precise and reproducibility.The results of pharmacodynamics show that Jiangzhijianfei Capsules can reduce the body weight, fat index, the volume of fatty cell and the level of serum cholesterol and low density lipoprotein of the obese rat caused by high fat nutritive feed apparently, and increase the quantity of fatty cell and the level of serum high density lipoprotein significantly. At the same time, the acute toxity test and long-term toxity test show that the Capsules have no toxic and side effects, it is very safe for clinic. These results can provide reliable evidence for the use of the Jiangzhijianfei Capsules.
|
PDF Full Text Request