Building An Air Cavity Of Axillary Fossa With Mastoscopy And The Safety Research On CO₂ Cavity

Objective: To investigate the feasible of mastoscopy on swine by building an air cavity of axillary fossa and the effect of an artificial CO₂ cavity on breast cancer cells. Methods: A CO₂ cavity of porcine armpit was built, then the arterial blood gas of swine was measured and the effect of UHS on ultrastructure of nerve was measured. With an artificial CO₂ cavity model in vitro, cell growth, cell apoptosis, cell adhesive power and ICAM-1, CD44v6 were measured by FCM and RT-PCR et al. Results: The CO₂ cavity can be built safely and quickly through liposuction. The effect of CO₂ cavity on porcine arterial blood gas was at range of organism adaptation. There was no significant effect of USH on neural ultrastructure. As the pressure increasing, the artificial CO₂ cavity can inhibit the growth of breast cancer cells, urge them to apoptosis, increase the expression of Fas/Fas-L, and the cell adhesive powe, the expression of ICAM-1 and CD44v6 were increased. Conclusion: The mastoscopy on swine is feasible and safe. More pressure of CO₂ cavity can cause breast cancer cells to apoptosis, immune escape and increase invasiveness of them, which should be thinked highly of by mammary surgery.