Changes In Protein Expression Profile Of Iron Deficiency Hearing Loss: An Experimental Study

To explore the changes of protein expression in cochleas of Wistar rats with iron deficiency hearing loss using shotgun proteomic strategy and Immunohistochemistric study.About 1000 proteins(MW from 8421Da to 1252882Da, PI from3.66 to 12.33 )were detected in each group( control, iron deficiency and Tiebifu group).Each group of proteins were classified and there were many difference proteins among the three groups.some differences were Validated by Immunohistochemistric study.our research showed that proteomic can be used in cochlea study and molecule mechanism of hearing loss caused by iron deficiency are revealed in protein level.