Effect Of Aluminum On Rat's Memory And Intervention Of Antioxidant Plant

Objective:To explore the impairment mechanism of Aluminum to memory drawback in rat, andthe prevention and cure function of antioxidant plants. Although aluminum (A1)contributes to a variety of cognitive dysfunctions and mental diseases, the underlyingmechanisms of A1 interactions with the nervous system are still unknown. By themethods of ethnology, electrophysiology, plasma chemistry and pathology, from theview of both Neurology and Neuroinformatics, on micro-and macro-levels of theneural system, the effects of preventing rats from memory drawback because of beingexposed to Aluminum (A1) for a long time were studied via red wine and traditional Chinesemedicine Liu wei di huang.Methods:Altogether 5 groups(10 rats for each group): (1) normal control group; (2) modelcontrol group; (3) red wine group; (4) pre-intervention group ofliu wei di huang; (5)cure group of liu wei di huang. Respectively administrated red wine and liu wei dihuang as medicine for a month before memory drawback models established. Exceptthe rats of normal control group, the others rats were fed by food withAluminum. Morris water maze test, plasma chemistry index SOD and MDA, long-termpotentiation and long-term depression (population spikes, PS) by performingelectrophysiological recordings and pathomorphism in hippocampus were measuredbefore and after exposing to Aluminum for emory drawback model.Results:1. Rat models were successfully established with severe learning and memorydefects by being exposed to Aluminum (A1) for a long time through PO. 2. All of the established memory drawback rat models in the group without anyintervention were verified by Morris water maze test, plasma chemistry indexSOD and MDA, long-term potentiation and long-term depression, andpathomorphism in hippocampus compared with the model control, group.3. Exposed to Aluminum caused a significant increase in lipid peroxidation productsThe model control group got worse results in Morris water maze test, plasmachemistry index SOD and MDA, long-term potentiation, long-term depressionand pathomorphism in hippocampus.4. The interventions of red wine and liu wei di huang could effectively facilitate spatiallearning and memory and enhance LTP and LTD in the DG region of the hippocampus inaluminum-induced learning and memory impairment in rats. The pre-interventions ofred wine and liu wei di huang and cure interventions of liu wei di huang weremore effective to prevent rats from memory drawback.Conclusion:The memory drawback rat models established by exposed to Aluminum for a longtime can simulate cognitive dysfunction and mental disease, expressing severelearning and memory impairments. This kind of memory drawback rat model ismore suitable for the study of prevention method because of long term exposed toAluminum. red wine and liu wei di huang are all effective to prevent rats from memorydrawback. Furthermore, The pre-interventions of liu wei di huang has more effectsthan pre-interventions of red wine and cure interventions of liu wei di huang do onthe neurons, synapses as well as learning and memory abilities caused by exposed toAluminum for memory drawback rat model being established.