Application Of Countercurrent Extraction And Membrane Separation Technology, Traditional Chinese Medicine Injection Process

The Radix Salvia miltiorrhiza solution for injection is recorded in the Health Department Standard of medicine and chemical reagents, which possess the function of promote blood circulation to remove blood stasis and nourish heart. According to the problems proved in the clinic use, it is necessary to study on it again by new extracting and separating techniques, as well as the form of freeze-dry.By inspecting the size of crude drugs, solvent, temperture, time and the units of extracting, the new technical parameters are determind, which consist of the characteristics of dynamic , phase , continuity and counter-current. The unstability of polyphenolic acids is solved with it.On the basis of differences between the molecular weight and dissolved qualities of the polyphenolic acids and impurities, the technological process of refine and purification is formed, that is alcohol precipitate, Microfiltration, Ultrafiltration. The main technical conditions are also selected.The freeze-dry method is defined with the preparation confecting liguid, the excipient of the bractet and the freeze-dry conditions.By comparing the qualities of the Radix Salvia miltiorrhiza power for injection and solution for injection with the components, stimulation and hemolysis, it indicates that the new process can promote the contents of effective composition, reduce the similation and increase the stability.