Supported Catalysts In A Palladium Catalyzed Reaction And Prochiral Ketones Asymmetric Reduction Reaction,

The ideal organic synthesis should produce the desired product in 100 % yield and selectivity, in a safe and environmentally benign process. Maximizing efficiency and minimizing costs constitutes one of the most exciting challenges of synthetic chemistry. Over the past decades, various efficient methods based on organometallic homogeneous catalysts have been developed. However, the high cost of the catalyst and the metal contamination of the product remain to be surmounted. The search for recyclable catalysts with low leaching level of metals has been constantly recognized as one of the prime concerns from both academic and industrial perspectives. Considerable efforts are being made to modify the performance in order to simplify the separation of the products and recovery of the catalysts. Various supported catalysts are useful approaches towards this goal. The linchpin of the strategies relies on the immobilization of the ligand onto a fimctionalized polymer backbone through covalent binding. In comparison to homogenous solution conditions, polymer-bound catalysis can facilitate the catalyst separation from the reaction mixture, simplify catalysts recovery and recycling, and eventually be prospective to meet the tendency of green chemistry.In this thesis, we mainly discuss two kinds of work. 1. Preparation of a Nafion-Teflon bimembrane-supported palladium catalyst and its use in the palladium-catalyzed reaction; 2. Preparation of polymer-supported Ru-TsDPEN catalysts and use it for enantioselective synthesis of anti-depress drug, such as Fluoxetine, Tomoxetine, Nisoxetine and Duloxetine.In the first part, we have developed a novel palladium catalyst supported on the perfuorinated Nafion-membrane, reinforced with poly(tetrafuoroethylene) fiber, has been prepared. The structural characterization of the supported catalysts has principally been performed by means of spectral analysis, including elemental analysis, ICP, reflective IR. The catalysts exhibit high activity and stability in the Suzuki coupling reactions, Heck arylation reactions of aryl iodides with olefins and Sonogashira couplings with phenylacetylene. The catalyst can be readily recovered...