| Chronic superficial gastritis (CSG) is a common disease, it has a high outbreak rate, it's due to various causes of gastric mucosal injury, it has no specific clinical manifestations, about half of the patients have upper abdominal discomfort, fullness, dull pain, burning pain with no specific regulation, usually getting worse after eating. Secondly, indigestion symptoms like loss of appetite, belching, heartburn, nausea is also common. Quite a lot of patients without clinical symptoms. Congestion, edema, hemorrhage, even erosive gastric mucosal inflammatory changes can be seen under gastroscope, its long course and relapse causes atrophic gastritis, and even cancer, have influence on the work and life of people, using Chinese medicine to treat CSG have the advantages of effective, less recurrence, low prices and less side effect.1. Literature reviewObjectiveThis part outlined the recent progresses in the TCM and western medicine researches on Chronic gastritis (CG).MethodsThrough summarizing these documents from the system of CNKI, mengfung> PubMed.ResultsFirst, it introduces the western medicine progresses in epidemiology, pathogenesis, standard clinical diagnostic and various treatments. And meanwhile it introduces the TCM understanding to the disease name, etiology, and pathogenesis of CG, and the progresses in syndrome differentiation, all kinds of treatments in herbal medicine, acupuncture, Tui Na massage, and integrated Chinese and western medicine and analyses the curative effect of these treatments.ConelusionsThe literature review says the existing problems and research foreground of CG. Above all, these theories provide basis for the TCM research in CG.2. Clinic StudyObject iveTo explore the therapeutic effect and mechanism of repress liver and reinforce spleen method in treating in-coordination between liver and stomach syndrome of Chronic superficial gastritis (CSG) and show the safety of repress liver and reinforce spleen method.Methods1. This research was based on91cases of outpatients from Subsidiary of the Guangdong Provincial Hospital of Guangzhou University of Traditional Chinese Medicine Ershadao hospital outpatient and Hong Kong Pok Oi Hospital Chinese Medicine Clinic during November2010-october2011who meet the diagnostic criteria of Chronic superficial gastritis (CSG) of western medicine, and the in-coordination between liver and stomach syndrome of TCM. They were randomly divided into two groups. One group is the treatment group,51patients of which were treated with unblocking liver and regulating flow of Qi, regulating stomach and dissipating sorrows, Xiao chai hu Soups,150ml, two times a day. The other group is the control group, with40patients being treated with Chai hu shu gan powder,150ml, two times a day. The cases of both groups are treated4weeks and followed up1month. There was no statistical difference between two groups in age, sex, course, and scores of traditional Chinese medical symptoms(P>0.05).2. This part make a safety observation (Blood, urine, stool routine, ECG, liver function (ALT), renal function (BUN, Cr), glucose (Glu), electrocardiogram) and clinical observation. Finally, after collection of clinical data, establish a database, according to the requirements for statistical analysis, counting data using the X2test, measurement data using the t test, comparison between two groups using independent t test.Results1.Treatment group total effectiveness is96.08%. Control group total effectiveness is100%. Treatment group total effectiveness surpasses the control group total effectiveness is not obviously (P>0.05)2. Two groups of patient's symptom total integral has the obvious difference before the treatment and the latter (P<0.05). The treatment group Chinese medicine symptom total integral's improvement is as good as the control groups.3. There is no statistically difference in safty indicators such as WBC, RBC, Hb, PLT, ALT, AST, BUN, Cr, Glu AND ESR between the treatment group and control group (P<0.05).Conclusions1. Above all, unblocking liver and regulating flow of Qi, regulating stomach and dissipating sorrows appears to have the significant effect in the treatment of in-coordination between liver and stomach syndrome of CSG. It has improve the clinic syptoms, TCM syndrome and the quality of life of CSG patients.2. In this study, treatment group used unblocking liver and regulating flow of Qi, regulating stomach and dissipating sorrows, achieved good clinical efficacy, further evidence that in-coordination between liver and stomach syndrome is the basic pathogenesis of traditional Chinese medicine of Chronic superficial gastritis (CSG).3.The trial shows the clinic safety of Xiao chai hu Soups. |
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