Association Research On Symptoms Of "Toxin Damaging Brain Collaterals" And Laboratory Parameters In Stroke

Based on clinical investigations and laboratory parameters, analyz the relationship between nonspecial symptoms, clinical syndromes and other factors. In order to find characteristics of nonspecial symptoms of "toxin damaging brain collaterals" in acute stage of stroke, we analyze dynamic evolvement rules and therapeutic efficacy of detoxification therapy and blood-activation therapy. Collection of ischemic stroke patients within72hours, randomly divided into Kudiezi group as treatment group and Xuesaitong group as control group. Collected information on the time of1week before strock, within72hours and the14th day after strock, including symptoms especially the nonspecific symptoms, measuring scales and laboratory parameters. The laboratory parameters included High-Sensitivity C-reactive Protein(Hs-CRP), Interleukin-6(IL-6), Oxidized Low-Density Lipoprotein(OX-LDL), Neuron-Specific Enolase(NSE), Matrix Metallopeptidase-9(MMP-9), Platelet aggregation(PAGT). The measuring scales including National Institutes of Health Stroke Scale(NIHSS), and Mini-Mental State Examination(MMSE). The5nonspecific symptoms involving emotional lability, goofy facial expressions, lack of strength, hypersomnia, head giddy.The results indicate that in the week before and72hours head giddy appears highest frequency, followed by lack of strength, goofy facial expressions and emotional lability, hypersomnia appears lowest frequency. The14th day after strock lack of strength appears highest frequency, followed by head giddy, emotional lability, and goofy facial expression, hypersomnia appears the lowest frequency. Within72hours, Hs-CRP, OX-LDL and IL-6showes the best correlation among the6laboratory parameters, IL-6and PAGT indicate better correlation. The14th day after strock Hs-CRP and OX-LDL indicate the best correlation, while IL-6and PAGT, NSE and MMP-9indicate better correlation. Hs-CRP, OX-LDL and IL-6has good correlationship with MIHSS and MMSE. Nonspecific symptoms'establish are relates to gender, NIHSS scores and MMSE scores. Within72hours and the14th day after strock, goofy facial expressions, lack of strength, hypersomnia and head giddy all relate to NIHSS scores and MMSE scores. Each specific symptom correlated with indexes, of which lack of strength, head giddy and hypersomnia, these three nonspecific symptoms have strong correlation to the indexes. There is the correlation between nonspecific symptoms total number and NSE, PAGT level. Changes of goofy facial expression, hypersomnia and head giddy are dynamic relate to laboratory parameters. There is also correlation between nonspecific symptoms and syndrome scores. The two therapeutic schedules all have the preponderance, Kudiezi focus on detoxification, so it improves symptom fire more obviously. Also improves symptom Yin deficiency superior to Xuesaitong group. Kudiezi can reduce MMP-9level.Acute stroke phase do exist a group of symptoms, those symptoms are not included in traditional six syndromes, but it appears high frequency in strock, and "toxin damaging brain collaterals" illness pathologenesis can interpretation. This group of nonspecific symptoms close and dynamic relation with inflammation, neuronal damage, and good correlation with nerve function defect, intelligence score. With detoxification therapy and blood-activation therapy, each index, syndrome, symptoms were well improved.