| Irritable bowel syndrome,(IBS) is a functional diseases, which is not a threat to the life, but its long course and relapse have influence on the work and life of people and results in the huge waste in medical and health resources. So IBS has aroused the attention of international medical community, the traditional Chinese Medicine raise the cure rate and reduce recurs in TCM syndrome differentiation, and the TCM gradually has superiority in IBS.1. Literature reviewObject iveThis part outlined the recent progresses in the TCM and western medicine researches on IBS-D.MethodsThrough summarizing these documents from the system of CNKI> mengfung^PubMed.ResultFirst, it introduces the western medicine progresses in epidemiology, pathogenesis, clinical diagnostic standard and various treatments. And meanwhile it introduces the TCM understanding to the disease name, etiology, and pathogenesis of IBS, and the progresses in syndrome differentiation, all kinds of treatments in herbal medicine, acupuncture, Tui Na massage, and integrated Chinese and western medicine and analyses the curative effect of these treatments.ConclusionsThe literature review says the existing problems and research foreground of IBS-D. Above all, these theories provide basis for the TCM research in IBS-D.2. Clinic Study Object i veTo explore the therapeutic effect and mechanism of bu pi yi shen in treating Spleen Yang-deficiency syndrome of irritable bowel syndrome-diarrhea(IBSHD) and show the safety of bu pi yi shen Soup.Methods1. This research was based on83cases of outpatients from Subsidiary of the Guangdong Provincial Hospital of Guangzhou University of Traditional Chinese Medicine Ershadao hospital outpatient and Hong Kong Pok Oi Hospital Chinese Medicine Clinic during November2010-october2011who meet Rome III diagnostic criteria and Spleen Yang-deficiency syndrome of TCM. They were divided into two groups randomly. The first group is the treatment group,43patients of which were treated with bu pi yi shen, Shen Ling Atractylodes Powder and Sishen Pill,150ml, two times a day. The other group is the control group, with40patients being treated with Shen Ling Atractylodes Powder,150ml, two times a day. The cases of both groups are treated4weeks and followed up1month. There was no statistical difference between two groups in age, sex, course, and scores of traditional Chinese medical symptoms(P>0.05).2. This part make a safety observation (Blood, urine, stool routine, ECG, liver function (ALT), renal function (BUN, Cr), glucose (Glu), electrocardiogram) and clinical observation. Finally, after collection of clinical data, establish a database, according to the requirements for statistical analysis, counting data using the X2test, measurement data using the t test, comparison between two groups using independent t testResult1. Treatment group total effectiveness is95.35%. Control group total effectiveness is95.00%. Treatment group total effectiveness surpasses the control group total effectiveness is not obviously (P>0.05)2. Two groups of patient's symptom total integral has the obvious difference before the treatment and the latter (P<0.05). The treatment group Chinese medicine symptom total integral's improvement is as good as the control groups.3.There is no statistically difference in safty indicators such as WBC, RBC, Hb, PLT, ALT, AST, BUN, Cr, Glu AND ESR between the treatment group and control group (P<0.05).Cone Iusions 1. Above all, bu pi yi shen appears to have the significant effect in the treatment of Spleen Yang-deficiency syndrome of IBS-D. It has improve the clinic syptoms, TCM syndrome and the quality of life of IBS-D patients. In this study, treatment group used bu pi yi shen, achieved good clinical efficacy, further evidence that Spleen Yang-deficiency syndrome is the basic pathogenesis of traditional Chinese medicine of irritable bowel syndrome-diarrhea(IBS-D).2. The trial shows the clinic safety of Shen Ling Atractylodes Powder and Sishen Pill. |
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