Effect And Mechanism Of Jiangzhi Capsules In Regulating Blood Lipids And Improving Vascular Endothelial Function

Objective:. To explore the effect and mechanism of jiangzhi capsules in regulating blood lipids and improving vascular endothelial function by observing the impact of jiangzhi capsules on blood lipids and inflammatory cytokines in elderly patients with coronary heart disease and dyslipidemia.Methods:200elderly patients with coronary heart disease and dyslipidemia were randomly divided into four groups according to the principles of randomized controlled method which include low dose simvastatin group (group A, simvastatin10mg qd), conventional-dose simvastatin group (group B, simvastatin20mg qd), jiangzhi capsules alone group (group C, jiangzhi capsules4tid) and the integrative medicine group (group D, jiangzhi capsules4tid and simvastatin10mg qd),50cases in each group. Venous blood were extracted and retained before and after8weeks'treatment respectively for preparing to be tested.Levels of serum lipids profile such as total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) and levels of serum inflammatory cytokines such as c-reactive protein (CRP), homocysteine (Hey), Von Willebrand factor (vWF), nitric oxide (NO) and endothelin (ET)were measured and compared. Other security data such as blood routine, urine routine, stool routine, liver function,renal function and ECG were also been concerned. Results:Compared with before treatment, jiangzhi capsules can significantly reduce levels of serum TC, TG, LDL-C, Hey, vWF and ET, increase levels of serum HDL-C and NO(P <0.05). Jiangzhi capsule alone can significantly improve levels of serum TG, HDL-C,Hey,and vWF, which better than that of conventional-dose simvastatin group (P<0.05). The efficiency improvement of serum CRP, ET and NO in jiangzhi capsule alone group is equivalent to that of standard doses of simvastatin group.The effect of jiangzhi capsule alone on reducing levels of serum TC, LDL-C is also equivalent to that of low dose simvastatin group.Jiangzhi capsules combined with low dose simvastatin were more effective than the other three groups in the improvement of levels of serum TG, HDL-C, LDL-C,CRP, Hey, vWF, NO and ET(P<0.05). In addition, the safety of jiangzhi capsule combined with low dose simvastatin is better than that of conventional dose simvastatin group, which showed well tolerated by elderly patients more than60years of age.Conclusion:Jiangzhi capsules can reduce levels of serum TC, TG, LDL-C and levels of serum inflammatory cytokines such as CRP, Hcy, vWF and ET, increase levels of serum HDL-C and NO in elderly patients with coronary heart disease and dyslipidemia. The effect of jiangzhi capsules combined with low dose simvastatin in regulating blood lipids and in improving vascular endothelial function is so more significant that it may be a safe and effective clinical treatment programs in regulating blood lipids of elderly patients with coronary artery disease.