Of. P38MAPK Macrovascular Complications Of Diabetes

Objective: We detected the expression of P38 mitogen-activated protein kinase (P38 MAPK) in perpheral blood mononuclear cells (PBMC) in patients with type 2 diabetic macroangiopathy, in order to study the role of P38 MAPK in patients with type 2 diabetic macroangiopathy.Methods: We examined 60 patients with type 2 diabetes (30 patients with macroangiopathy and 30 patients without macroangiopathy) and 30 normal controls. The protein expression of phospho-P38 MAPK was detected by Western blot and ELISA assay, and fast blood glucose (FBG), HbA1C and fast insulin (FINS) were determined.Results: The protein expression of phospho-P38 MAPK in patients with type 2 diabetes was higher than that in normal controls; The protein expression of phospho-P38 MAPK in patients with macroangiopathy was significantly increased as comparing with that in patients without macroangiopathy.Conclusion: The phospho-P38MAPK was a sensitive index of diabetic macroangiopathy, and its expression correlated with hyperglycemia, HbA1C and hyperinsulinemia. Strict control of hyperglycermia, HbA1C and hyperinsulinemia was the basement for preventing from diabetic complications.Key words: P38 mitogen-activated protein kinase; Diabetes; Macrovascular complications; Perpheral blood mononuclear cells...