Puerarin Dropping Pills, Preparation And Evaluation

Aim at high incidence of coronary heart disease at clinic, we choose Puerarin which from Chinese medicine Gegen that being used as food and drug as research object. Based on requirement of market and clinic, using Puerarin we produced pills.This preparation is solid arid can take orally.Seeking way in order to it can quickly exert action and solve the low bioavailability.So the main research content is the process and evaluation of preparation.Based on the research of Puerarin's character and stability, we selected the best composition of preparation and the optimization of processing technology by orthogonal experimental and uniform design.Simultaneously,the disperse state of Puerarin was observed.The experiment proved that the processing technology is stable and reasonable.Puerarin's exist form in preparation is molecules and crystallites or ultrafine powders.This indicate that Puerarin formed solid dispersion. The Puerarin pill's quality was estimated synthetically by the study of quality standard, bioavailability, pharmacokinetics and organise distrubting. The result of quality standard research proved that Puerarin pill is stable and controlable. The most important criterion to estimate Puerarin pill is Puerarin's oral bioavailability. It was found that, through determination of dissolution rate and plasma concentration, comparing with purarin tablets,Puerarin dipersible tablets and Yu Feng Ling Xin Pian, Puerarin pill is better than the other three ones no mater concerning in vitro dissolubility or pharmacokinetics.The determination results of Puerarin's organise distrubting in rabbit indicate that the quantity and concentration of Puerarin is enough in heart,the target of coronary heart disease.The research verified that Puerarin pill's procedure is stable and the quality is controlable.Comparing with the other oarl solid preparation,Puerarin pill have fast reaction and high bioavailability.