Relations And Of Tongxinluo Intervention Role Of Vascular Endothelial Function And Atherosclerosis

ObjectiveTo evaluate changes of vascular endothelium function in the rabbitsduring atherosclerosis and the effect of tongxinluo on vascular celladhesion molecule-1 (VCAM-1) , Monocyte chemotactic protein-1 (MCP-l)macrophage colony-stimulating factor (M-CSF) expression of the thoracicaorta, and serum total cholesterol serum NCK plasm ET level andatherosclerosis in the rabbit model induced by high-cholesterol Diet.MethodsThirty male rabbits were divided into three groups randomly: normal dietgroup, high-cholesterol group fed with 1.5%cholesterol diet,tongxinluo group fed with 1.5%cholesterol diet and tongxinluo0.72g/(kg. d). Serum total cholesterol, serum NCK plasm ET plaqueareas, ratios of intima/media thickness and radios of VCAM-1/GAPDHmRNA MCP-1 /GAPDH mRNA M-CSF /GAPDH mRNA of the thoracic aorta weredeterminate after twelve weeks .ResultsSerum total cholesterol level of tongxinluo group was decreased thanhigh-cholesterol group (P<0. 05) , and they were both much higher than those of normal diet group (P