| Bronchial asthma is commonly seen in clinical practice. With its incidence and mortalityrate increasingly rising year after year, this disease has been the hotspot of medical researchin recent years in our country and abroad. This disease, significantly impacting patients'quality of life(QOL), not only affects patients' daily-activity, but also impairs theiremotion, mental health and social function. The health of asthmatics are severely threatenedand the burden of the families and the society are heavy. It is of clinical importance andsocial value to explore effective ways to improve asthmatics' quality of life.Objectives: 1.The main aim of this study is to evaluate the treatment effects of the method buyifeishen(replenishing Qi of lung and kidney)on moderate persistent asthmatics and its impact onpatients' QOL. To explore the therapeutic mechanisms of this therapy and objectively evaluatethe theraputic effects of traditional Chinese medcine(TCM) on asthma in order to provideevidence for determining effective interferance of asthma by TCM. 2.To study the relationshipbetween QOL and other clinical outcomes such as TCM syndromes in order to provide evidencefor determining effective evaluation system of asthma treatment by TCM. 3.Analyzing theinfluencing factors of asthmatics' QOL.Methods: In this randomized, open-labeled, parallel-group study, sixty patients with moderarepersistent asthma have been randomized into experimental group and control group. Accordingto the guidelines on asthma management by British Thoracic Society and Chinese MedicalAssociation, Inhaled corticosteroid and as-needed β-agonist were used in the treatment ofthe experiment group while this therapy plus dongchongxiacao capsule were used in the controlgroup for two months. After 2 months the observation continued untill 6 months afterrandomization. Patients' QOL were assessed by AQLQ and SF-36 at randomization, 1, 2, 3, 4,5, 6 months after randomization. Patients' symptoms, TCM syndromes, asthma attack incidence,noctural awakenings, dosage of β-agonist and corticosteroid, therapy steps, symptom-freedays were assessed at randomization and 2, 4, 6 months after randomization. Pulmonary functiontesting and blood testing were performed at randomization and 2 months after that.Results: Significant treatment effects(P<0.05) were found in the physical function, role-physical,mental health and role-emotional of the generic SF-36 for the experiment group compared withthe control group. Greater improvements in all the AQLQ domains (activity limitations, asthmasymptoms, mental state, response to environmental exposure and care for one's own health)andmean AQLQ overall, as well as bodily pain, vitality, general health of SF-36 had been observedin the experiment group but didn't reach the statistically significant level. Pant, cough, phlegm spitting, chest tightness, wheeze, symptoms overall changed greatlyin both groups.However, the experiment group had experienced greater improvement in overallsymptoms(P=0.05), chest tightness(P<0.01), pant(P<0.001) than the control group.The curativerate and total effective rate in the experiment group were 13.3% and 63.3%, significantlyhigher than that of the control group, which were 8.7% and 25.1%. Shortness of breath, lassitude, lack of strengh to speak, accidie, easiness to get coldand syndromes overall were ameliorated in both groups. Greater improvements were seen inshortness of breath, lassitude, daytime perspiration, accidie, syndromes overall for theexperiment group compared with the control group (P<0.05).The curative rate and totaleffective rate of dizziness, tinnitus, tartness of waist and knee, easiness to get cold, fearof wind and cold, pale complexion, frequent urination, libido impairment were higher in theexperiment group than the control group, but statistical analysis didn't produce significantresults. The curative rate and total effective rate of syndromes overall in the experimentgroup were 3.3% and 60.0%, significantly higher than that of the control group,which were0% and 26... |
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