Pharmacodynamics And Mechanism Of The Dsf Treatment Of Coronary Heart Disease

Compound traditional Chinese medicine of DSF is bases on the long-term proved effective traditional Chinese medicine prescription for coronary heart disease.By means of pathological chromatic image analysis system, immunohistochemistry, we have observed that the effects of DSF on rat model of acute miocardial infarction such as anti-miocardial infarction, anti-platelet,anti-thrombus, improving blood circulation etc.The experimental study was expected to explain what the mechanism of QKN on coronary heart is,especially in the view of gene expression. The results indicate that:1. DSF has assured therapeutic effects on experimental rat model of coronary heart disease.It can inhibit the hoist of ST segment caused by ligating the front branch of coronary artery, reduce the area of miocardial infarction,lower the proportion of the area of miocardial infarction to dangerous area,lower the level of AST,LDH and CK-MB on occur of miocardial infarction, inhibit the conglomeration of platelet caused by ADP,AA,CG, postpone the experimental rat thrombus, reduce the thickness of blood and plasma,debase blood pressure,the resistance of coronary artery and the total periphery resistance.2. The mechanism of anti-coronary heart disease effects has close relationship with such factors as below:...