Inhalation Anesthetics On Myocardial Function

Objective: To Creation a methodology on evoking ventricular fibrillation by electric shock. Methods: Male New Zealand white rabbit 42, weight range 2~2.5kg were chosed. The experiment include three parts: The first steps: 6 rabbits were gave electric shock with 10, 15, 20, 25, 30, 35V under 1 MAC anesthesia. The second step: 30 rabbits were gave electric shock with the subthreshold of evoking ventricular fibrillation under different concentration of volatile anesthetics. The third step: 6 rabbits were gaven electric shock 6 times with the subthreshold under 1MAC anesthesia. Result: Subthreshold of evoking ventricular fibrillation is 25V; The subthreshold of evoking ventricular fibrillation is easier to evoke vetricular fibrillation by increasing the concentration of volatile anesthetics, and the subthreshold did not damage heart by increasing times of electric shock under 1MAC aneshtetics. Conclusion: Subthreshold of electric shocks (25V) have little damage on heart and have high sensibitity to find the response of heart to change of anesthetic concentration.