Chinese Han Population The Apm1 And Plin Genes, Variation And Hypertension With Obesity Association Studies

Background The view of adipose tissue has dramatically changed over the last decade. Once considered as an inert energy depot, adipose tissue, has been found serving as an important endocrine organ regulating whole-body metabolism by secreting several molecules into circulation. Insulin resistance is widely viewed as a common basis of the etiology of metabolism syndrome including obesity, type 2 diabetes as well as essential hypertension. Adiponectin, one of the adipose tissue-derived proteins, which is abundantly expressed in adipose tissue, is encoded by APM1, also known as GBP28, Acrp30 and adipoQ. Recent studies suggested that the adiponectin gene polymorphisms were associated with insulin resistance and type 2 diabetes in Asian and European populations. Perilipin, the most abundant protein coating the surfaces of lipid droplets in adipocytes were demonstrated to play an inpormant role on lipid motabolism by inhibiting lipolysis of triacylglycerol in adipocytes in vivo and in vitro. The entire DNA sequence of human perilipin gene (PLIN) was first released on GenBank in May 2002. Studies foucusing on the association between genetic variation in human PLIN and metabolism related disorders have not previously been reported. The purpose of this study is to investigate whether the genetic variants in APM1 and PLIN gene were associated with the combination of hypertension and obesity (HO) and related features in Chinese.Materials and methods-A case-control design was applied, and 536 unrelated cases and 525 controls were recruited from hospitals and communities in Beijing metropolitan and Shanxi province. Inclusion criteria for cases were as follows: 1) 20-69 years of age; 2) Chinese Han nationality; 3) systolic blood pressure (SBP) ≥160 mmHg...