The Clinical Pathological Features And Carcinogenesis Of Familial Colorectal Cancer

To analyze the clinical and pathological features of Familial Colorectal Cancer (FCC); to study the molecular characteristics of FCC and to search for the carcinogenesis of FCC. Unlike Hereditary Non-polyposis Colorectal Cancer (HNPCC) and Sporadic colorectal cancer (SCRC), FCC had the features were as follows: early onset, relative proximal colon location, poorly differentiation, low tumor infiltrating lymphocytes, concomitant polyps, etc. There were no significant differences of the expression ofβ-catenin,nm23,TopoⅡ, among FCC,HNPCC and SCRC group(P>0.05). The abnormal high expression of P53 in HNPCC and FCC groups were lower than that of SCRC group(P<0.05). There was no significant difference between FCC and HNPCC groups(P>0.05). The ki-67 expression in SCRC group was higher than those of FCC and HNPCC groups(P<0.05). The incidence of hMSH2 deletion in HNPCC group was higher than that of the FCC and HNPCC groups (P<0.05). The percentage of MSI-H in FCC group were higher than that of SCRC group(P<0.05). The MSI-H tumors in FCC correlated with the deletion of hMLH1 expression(P<0.01). The deletion of hMLH1 expression correlated with the methylation of the promoter of hMLH1(P<0.01).In conclusion, FCC had special clinical and pathological features, molecule expression. MSI related with the methylation of the hMLH1 promoter may play an important role in FCC carcinogenesis.