| Objectives1. To learn about the general picture of patients with transient ischemic attack (TIA).2. To explore evolution of the definition, risk factor/etiology, imaging manifestation of cerebral artery, the related factors of prognosis and the clinical character of young patients.Material and methods1. 822 patients with TIA between 1990 and 2008 were observed.2. The distribution of time which clinical manifestation lasted was analyed, and ischemic focus in different lasting time was compared by X2 test.3. Risk factors were compared in different gender, age and ischemic territory by used of X2 test. The possible etiology was analyzed according to the standard of TOAST typing.4. Analysis the percentage of arteriostenosis and distribution of stenosis artery in different groups. The distribution of stenosis artery in different gender and age was observed.5. The short-term prognosis of 822 patients with TIA was summaried. The related factors of the short-time prognosis were analyzed by logistic regression model.6. The clinical character of patients less than 46 years was anlyzed in comparison with those older than 45 years by univariate analysis.Results1. The percent of male and female was 77% and 23% respectively. The median was 68. 62% patients were internal carotid artery (ICA) TIA, and 38% were vertebrobasilar artery (VBA) TIA. 2. Duration time of patients within 10 minutes, 1 hour, 3 hours, and 6 hours were 41,6%, 74%, 87%, and 96% respectively. Ischemic focus detected by CT/MRI/DWI was not found to be significantly different in the different duration time.3. The common risk factor was found in 89% patients, while the rare risk factor was found in 4% patients. Diabetes and smoking were more frequent in male patients. Comparing with VBA-TIA patients, ICA-TIA had more hypertension, and less alcohol abusing. The proportion of hypertension, diabetes, and hypercholesterolemia were increased with increasing age, while smoking and familiar history was decreased.The stenosis of responsible artery (39%) was the main risk factor, while 1/3 patients had no obvious cause.4. The occurrence of extracranial artery stenosis, intracranial artery stenosis, multiple intra-and extracranial stenosis was different statistically between ICA-TIA (5%, 58%, and 38%) and VBA-TIA (21%, 43%, and 36%). The distribution of arteriostenosis was different in different age groups. Intracranial artery stenosis decreased, while multiple intra-and extracranial stenosis increased gradually with increasing age.5. Hemiplegia, responsible artery stenosis, fragile plaque, ICA territory were independent risk factors of short-time prognostic. Anti coagulation therapy was favorable.6. Attacks lasted longer than 30 minutes, attack frequently, ischemic focus between in patients under 45 years (37%, 44%, and 50%) and older than 45 years (49%, 32%, 72%) were different. Familiar CVD history in young patients(37%) was more frequent than in older patients(22%), while hypertension, diabetes and responsible artery stenosis were frequent in older patients(68%, 23%, 67%) than in young patients(42%, 5%, 52%).Conclusions:1. The new definition of TIA wasn't suitable to some patients with TIA, which should be diagnosised by classic definition.2. 2/3 patients were caused directly by artery stenosis, but 1/3 patients were cryptogenic.3. Responsible artery stenosis, fragile plaque, and ICA-TIA were independent risk factors of short-time prognostic. Anti coagulation therapy was favorable.4. Under 45 years old, there were shorter attack lasting time, more attack frequence, higer family history, low percent of ischemic focus, hypertension,diabetes and artery stenosis.
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