Establishment Of A Metabolic Syndrome Related Non-alcoholic Steatohepatitis Mouse Model & Studies On The Effects Of EGB761 On Metabolic Syndrome And Its Mechanisms

The prevalence of metabolic syndrome,which is characterized by obesity, insulin resistance and dyslipidaemia,has increased dramatically accompanied with the changes of life style and diet composition.As a hepatic manifestation of metabolic syndrome,non-alcoholic fatty liver disease(NAFLD) also becomes prevalent and includes simple steatosis,non-alcoholic steatohepatitis(NASH) and liver cirrhosis.Non-alcoholic steatohepatitis(NASH),a crucial stage of NAFLD,leads to liver cirrhosis.The pathogenesis and the treatment of NASH are not clear and need further research.As to the treatment of metabolic syndrome, natural products that are safe and have multiple pharmacological effects could be potential therapies,because of the complexity and chronic intervention of metabolic syndrome.Ginkgo biloba leavesare such kind of natural product and has been widely used in clinic both in and outside of China.As a standardized and well-defined product of Ginkgo biloba leaves,EGB761 not only has anti-oxidant and anti-inflammation activity but also could improve serum lipid profiles and hyperglycemia in type 1 diabetes rat model.Focused on above two aspects of metabolic syndrome,two parts of work are presented in this dissertation and named as "Establishment of a metabolic syndrome related non-alcoholic steatohepatitis mouse model" and "studies on the effects of EGB761 on metabolic syndrome and its mechanisms".