Evaluation Of Radiation-induced Lung Injury In Rabbit With Multislice Spiral CT

Objective To evaluate the practicability and rationality about the establishment of the radiation-induced lung injury rabbit model and the application value of multislice spiral CT(MSCT) in rabbits with radiation-induced lung injury.Methods1. The establishment of radiation-induced lung injury rabbit model. One hundred Forty rabbits were divided into the normal control groups and six experimental groups randomly, and the six experimental groups received a single dose of 30Gy, 40 Gy, 50 Gy, 60 Gy, 80 Gy and 100 Gy respectively to the right lung. MSCT images were obtained in different groups at 3rd, 6th, 9th and 12th week respectively after the radiation. And the changes of the MSCT images related to radiation were evaluated by different physicians.2. Evaluation of radiation-induced lung injury in rabbit with multislice spiral CT.Forty rabbits were divided into the normal control groups and experimental groups randomly, and the latter groups received a single dose of 50Gy to the right lung. MSCT images were obtained on the 3rd, 5th, 7th, 8th, 11th,14th day, and 3rd, 5th, 8th and 12th week, pulmonary density of both right and left lung were assessed with pulmo of automatic evaluation software.Result The rabbits of the 60 Gy, 80 Gy and 100 Gy radiation dose group can not tolerance the high dose radiation. The changes of the MSCT images for the other four groups were evaluated. Ground-glass opacity, patchy consolidation and high density fibrosis were observed on the MSCT images of the rabbits. The incidence rate of radiation-induced injury was different between four groups. Radiation dose with 50 Gy was the optimal dose for the establishment of the radiation-induced lung injury rabbit model. The MSCT images of rabbits were normal in two weeks, while analysized by pulmo of automatic evaluation software, it was shown that the density of right lungs were higher than that of left lung after the 7th day(p<0.05). Various CT findings including ground-glass opacity, patchy consolidation and high density fibrosis were observed at the scheduled study.Conclusion The method of establishing the radiation-induced lung injury rabbit model is feasible. And 50Gy was the optimal dose for the establishment of the radiation-induced lung injury rabbit model. It plays an important role for MSCT to diagnose radiation-induced lung injury, and the early diagnosis radiation-induced lung injury can be done with pulmo of automatic evaluation software.