Mechanism Of Eliminating Blood Turbid Principal In Treating Hyperlipidemia MCAO Rats

Objective:To issue the basis of theoretic foundation of eliminating blood turbid principal in treating hyperlipidemia MCAO rats, to observe the effect and molecular mechanism of eliminating blood turbid therapying hyperlipidemia ischemic cerebral injury. Methods: Based on theory of blood turbid, we develop Hua-zhuo-xing-xue decotion, and apply it in the following experiment research. We establish the hyperlipidemia Middle cerebral artery occlusion(MCAO) rats, for the research of focal cerebral ischemic. In order to evaluate the therapeutic effects of Hua-zhuo-xing-xue decotion, we observe the changes in hyperlipidemia MCAO rats on blood fat,hemorheology,t-PA,PAI-1,D-Dimer,P-selectin,E-selectin in the hyperlipidemia MCAO rats'serum in order to find out characteristic appearance of blood turbid. Results: Hua-zhuo-xing-xue decotion can significantly improve the blood fat,hemorheology,t-PA,PAI-1,D-Dimer,P-selectin,E-selectin on hyperlipidemia MCAO rats.Conclusions: Blood turbid is the common pathway through the hyperlipidemia and ischemic stroke. Hua-zhuo-xing-xue decotion can protect the never system, and that is the molecular mechanism of therapeutic effect on eliminating blood turbid principal in treating hyperlipidemia ischemic cerebral lesion.