Relationship Between NQO1C609T, RAD51G135C And XRCC3C241T Single Nucleotide Polymorphisms And Acute Lymphoblastic Leukemia

Objective To investigate the effects of NQ01_C609T,RAD51_G135Cand XRCC3_C241T genotypes on the acute lymphoblastic leukemia(ALL) susceptibility.Methods NQ01_C609T,RAD51_G135C,XRCC3_C241T genotypes were detected in 170 patients with de novo ALL and 458 controls by PCR-RFLP.Results Polymorphisms in NQ01_C609T,RAD51_G135C and XRCC3_C241Tgenes did not seem to play an important role in the aetiology of ALL independently.To assess gene-gene interactions,NQ01_C609T was considered together with RAD51_G135C and XRCC3_C241T genes.The combined presence of both variant NQ01_C609T and RAD51_G135C alleles appeared to confer an increased risk of acute lymphoblastic leukemia with myeloid antigen and ALL with translocations among the carriers(OR=5.553 and 2.618 respectively),The presence of homozygosity for NQ01_C609T appeared to confer an increased risk of ALL in the country-children(OR=2.541).Conclusion The combination of might contribute to the leukemogenesis of ALL,and the combination of susceptibility variants is more predictive of the risk for ALL than either of them independently.