Clinical Research On Treatment With The Chronic Prostatitis Without Inflammation By Ziniliqishuganfang (ZNF)

Chronic prostatitis (CNP) was a common disease, also was a frequently encountered disease in the male urinary and genital system. CNP would harm to the patients'physical and mental health with complicated symptom and long course of disease,accompanying with neurastheria,sexual disturbance and barrenness, which given the patient more physical painful. CNP could be divided into three categories:bacterium type,nonbacterial type and prostatalgia type. Bacterium type was the main type in the clinic. Chronic prostatitis without inflammation was usually found in department of male,department of urology,department of skin and venereal disease and department of TCM which harmed mostly to young-aged and middle-aged man. It was belong to the category "Jingzhuo" in the TCM and was one of difficult treating disease, because it has characteristic of hard recovering and easy recurring and also hardly harm to the reproduction health. The case rate was only lower than benign prostatic hyperplasia (BPH) and carcinoma of prostate (CAP). So it has important significance for raising the quality of life and potentia generandi if the CNP was efficiently and positively prevented and cured. With the advantages of determine the treatment based on differentiation of symptoms and signs in TCM. The method of Chinese medicine treatment for CNP had superiority of improving the symptom and curing the disease.ObjectiveTo observe the clinical effect and safety and found the base for the further clinical and theoretical development by evaluating the effect of Ziniliqishuganfang (ZNF) treating the Chronic prostatitis without inflammation.MethodsThe candidates that were consisted with the standard of depression of liver-QI in TCM and Chronic prostatitis without inflammation in western medicine divided into two groups. The one group was treated by ZNF, the other group was treated by Qianliekang Tablets (QLT). To observe the clinical effect and safety with the observation index of curative effect,NIH-CPSI score,liquor prostaticus routine score,prostate tenderness score,flow rate of urine and prostate hypersound test. Statistical methods:The classification data was observed usingχ2 test and the ranked data by Wilcoxon rank-sum test. T-test or Wilcoxon rank-sum test was applied for group comparison. Matched t-test or Wilcoxon matched-rank-sum test was applied for self-AP:PA comparison. ResultsThe 70patients that were consistent with standard of diagnostic criteria were divided into ZNF group and QLT group in random. Each group was 35 cases. General investigation data showed that the average of patients'age was 36.7±5.9years old and the course of disease was 36.8±7.2 months. Compared with the curative effect on symptom of Chinese medicine within two groups, it was showed that the clinical recovery rate of the treatment group was 68.57%. While in the control group, the clinical recovery rate of the treatment group was 22.86%. There was significant difference between two groups(P<0.05). It showed that ZNF group had good effective for treating Chronic prostatitis without inflammation. Both two groups had significant difference between before and after treatment for decreasing NIH-CPIS score, and the NIH-CPIS score of ZNF group was lower than the control group (P<0.05). It was considered that the ZNF group was better than the control group. And also were the prostate tenderness score and the flow rate of urine. To compared the improving rate of symptom and physical sign for the disease, it was presented that the ZNF group had better curative effect on improving the frequent micturition,urgency,hard to urinate and frequent nocturia than the control group. Both two groups had no evident adverse effect. Blood test,urine test,stool test and liver-renal function test had no abnormal change and adverse reaction. It was presented that these two groups treatment was safe.ConclusionThe clinical study was showed that the method of regulate QI and disperse the depressed liver-energy has advantage as follows:the treatment group could improve the symptom of Chronic prostatitis without inflammation and the index of urodynamic study; The treatment group had the advantage for treating the Chronic prostatitis without inflammation and had not significant adverse reaction; The treatment group could improve the quality of life and better than the control group and was safe. The study was presented that the method of regulate QI and disperse the depressed liver-energy for treating the Chronic prostatitis without inflammation disease was an important therapeutics and was a new way of treating the disease.