Diabetic Nephropathy Syndrome Intervention Study Of The Evolution Of Chinese Medicine

ObjectiveTo discuss the Evolution of TCM syndrome of diabetic nephropathyâ…¢andâ…£and the influence to the syndrome by either Chinese herbs and Irbesartan aiming to lay a foundation for the Evolution of TCM syndrome in this flied.MethodsThe research had been carried out with a RCT, collecting the Diabetic Nephropathy sufferer came from Dozhimen Hospital of Peking Chinese Medicine University and 9 other hospitals.General informations, four diagnostic methods information from the starting point wre collected and the other 3 times of four diagnostic methods information of TCM while the patients got treatment were also collected, totally information of 4 times of one year. The data was kept by a database after confirmationClinical Sydrome Study 1:Descriptive and chi-square were adopted for the distributing of TCM syndrome; while accumulation analysis for syndrome elements.Clinical Sydrome Study 2:Repeated measures GLM were used to analyze the changing of the syndrome elements marks,the effection of the Irbesartan and the herbs and also the interaction of the grouping and DN stage.Clinical Sydrome Study 3:Factor analysis was used for categoryg the patients according to different syndromes. Transition probability matrix was used to analyze the evolution of the syndrome and the evolution of the nature of the disease.ResultsWe discovered that there are different symptom, syndrome, syndrome elements of highest frequency for either stage of DN.There was difference of yang deficiency (X2=11.579 P=0.001) and dampness turbid (X2= 13.478 P=0. 000) between the two stages,Compared with phlegm dampness and dampness turbid, blood stasis were more frequent and it appeared early in DN.TCM group and the WM group got significant changing in the 7 syndrome elements. For most of the syndrome elements there were no differents between the changing, but for qi deficiency syndrome element TCM group got a better result comepared with the WM group.The result of the disease nature study showed that most common disease nature is deficiency and excess,which was also stable.Neither pure deficiency and pure excess got much frequency,nor was the stability.Patients had been categoryied into 8 gourps for point 0,10 groups for point 1 and 9 groups for point 2. Some of the original syndrome last till next point, there were varieties of changes of the syndrome,there were still some paths:yang deficiency turned out to be yang deficiency and dampness and phlem,yin deficiency,turned out to be yin qi yang deficiency.qi deficiency and phlem and dampness turned out to be qi deficiency and phlem and dampness and dampness turbidConclusion1.There were differences between the of the two stages.As a process the Pathogenesis was beginning as "inner heat hurt qi "towards "yinyang deficiency". Yang deficiency was gradually apparent during the course. Phlegm dampness and dampness turbid were key pathological factors " 2.The results of GLM analysis showed that syhdrome elements marks had all decreased through the period significantly,TCM got a better result in qixu syhdrome element while the results of the other syhdrome elements were close.So the idea of disease and syndrome unifying wre highlighted.3. The nature of DN was deficiency and excess, the pathogenesis could be stages.The same stage seemed to have the same pathogenesis, the changes of the syndrone were various,as a result stage differentiation syndrome was recommend.