Naringin Benefits The Recovery Of Rats With Traumatic Brain Injury Through Attenuating Oxidative Stress And Inflammation

Objective:To study the role of naringin in treating rats with traumatic brain injury (TBI) and its possible mechanism.Methods:Rats were randomly separated into four groups. Rats in group A were sham-operated; in group B received TBI operation; in group C were treated with naringin for 7 days after TBI; while naringin were given continually for 7 days either pro-or post-TBI. The TBI was induced by weight drop technique and naringin was given orally 50mg/kg per day. Volume of damaged cortex, tissue water content, neurological score, SOD and MDA in serum and damaged brain cortex, il-1βand iNOS expression in cortex, as well as NO, were detected with respective methods.Results:Comparing with group A, rats in group B showed significant brain edema, bigger volume of damaged brain cortex, and obviously sensor motor dysfunction. However, the brain edema and damage volume were reduced and behaviors was improved in rats of group C and D, comparing with rats in group B. Measurement of SOD and MDA showed that naringin elevated the activity of SOD, and reduced MDA content both in injured brain cortex and serum. And, the expression of il-1βand iNOS, as well as NO were reduced by naringin, since the obvious elevation of them appeared after TBI. Meanwhile, all those changes were more significant in group D than in group C.Conclusion:Oxidative damage and inflammation were enhanced after TBI, which seems to be important factors for secondary brain damage. Naringin treatment can attenuate the neuropathological damages and improve the functional recovery of rats after TBI, partly through weakening oxidative damage and inflammation. Comparing with treatment post-TBI, naringin also given as prophylactic treatment shows better effect on protecting brain.