The Epidemiological Investigation About The Syndrome Pattern Distribution Regularity And Health Status Of Women With Climacteric Syndrome Through The Cross-sectional Epidemiological Study

Climacterium is a special physiology stage that every women should come through. According to report from domestic or abroad, about 90% women have different kinds of clinical symptoms during the age of 45 to 55. Climacteric Syndrome is a series of symptoms mainly due to autonomic nerve system dysfunction which happen during this special stage. Modern medicine treats mainly with hormone replacement therapy (HRT), but this treatment has some potential risk and adverse effects. While traditional Chinese medicine which lowers the side-effects has its unique characteristic and predominance under the direction of entirety concept. However, the symptoms of Climacteric Syndrome are complicated, and have different kinds of dialectical patterns. Each pattern interlaces and mixes together, which is not good to carry out personal therapies, therefore it is necessary to consummate the dialectical system of Climacteric Syndrome. ObjectiveWe make the epidemiological investigation about the syndrome pattern distribution regularity and health status of women with Climacteric Syndrome through the cross-sectional epidemiological study, in order to standardize the clinical trail of Climacteric Syndrome, gain a good social effect, establish the evaluation system of the clinical trail and new drugs development, and provide rigorous data of scientific research.MethodsWe use the questionnaire, follow the investigation methods of clinical epidemiology, design unified clinical scales include constitution,clinical symptoms and syndrome patterns of women with Climacteric Syndrome, inquest patients one by one and complete the scales. The differentiations are made by senior professors of traditional Chinese medicine based on his experiences. The observation index due to menstruation and leucorrhea,blood-serum level of E2 and FSH,living quality. We divide the objects into two groups (peri-menopausal group and post-menopause group), compare the differences in the index of the two groups.ResultsWe collecte 208 cases, eliminate 8 mistaken and defect cases,200 cases left are valid, during which response rate was 96.15%. There are 100 patients in the peri-menopausal group and 100 in the post-menopause group.Menopausal age:200 patients, age from 42 to 65, menopausal age from 46 to 53,48.07 in average, younger than those reported, which shows that the stress that women suffered today was harder.Scores of Climacteric Syndrome:Kupperman scores of post-menopause patients is higher than the peri-menopausal ones. The disparity is statistically significant (P<0.05), which shows that the symptoms of the post-menopause patient is more serious than the peri-menopause ones, especially in insomnia,dizziness,fatigue and palpitation.Symptoms of gynecology:menstrual disorder,hyposexuality,leucorrhea disorder and vagina abnormality are symptoms happened frequently in Climacteric Syndrome. Hyposexuality and vagina abnormality in post-menopausal patients are more frequent than the peri-menopausal ones (P<0.05), which shows that menstrual disorder and disharmony of the sexual life may happen ahead of schedule.Clinical symptoms and signs of traditional Chinese medicine:hectic fever,pharyngoxerosis,insomnia,restlessness,forgetfulness,sore waist,anxiety and fatigue are symptoms happened frequently in Climacteric Syndrome, especially symptoms of the liver and kidney meridian, which shows that the pathogenesis of the Climacteric Syndrome mainly are yin asthenia,blood deficiency,qi-stagnation and qi-deficiency, related to liver(stagnant),kidney(deficient),spleen(deficient),heart (deficient) and et cetera.Syndrome patterns:hepatic and renal yin deficiency happens most frequently (99 cases, about 49.5%), depression of liver-qi comes next (84 cases, about 42.0%). Imbalance between heart-yang and kidney-yin occupies 7.5%. The patterns of merely deficiency of kidney-yin and kidney-yang are less seen. There is no statistical significance in the syndrome patterns between post-menopausal and peri-menopausal patients(P>0.05).Sentiment:in the study we find different kinds of psychiatric symptoms of patients with Climacteric Syndrome, among 200 patients, there are 101 with deprementia, about 50.7%; 167 with anxiety; about 83.7%; 170 with restlessness, about 85.2%; 110 with hyposexuality, about 55.0%; 107 with vagina abnormality, about 53.5%. All of this shows that abnormal feeling and disharmony of the sexual life may be the key-point due to Climacteric Syndrome.Living quality:there is statistical significance in scores of PF,RP,VT,RE,MH between post-menopausal and peri-menopausal patients (P>0.05). In the comparison, the scores of physical function,body role and energy of the peri-menopausal ones are higher than the post-menopausal ones, while the scores of sentimental role,mental health of the peri-menopause ones is lower. The results show that the living quality obviously steps down in the post-menopausal patients. The sentimental role,mental health of the peri-menopause ones is worse than the post-menopausal ones, that may because women are not adaptation when step into the menopausal period. Conclusion1. There are 200 patients with Climacteric Syndrome in the study, whose menopausal ages are between 46-53, average in 48.5.2. The syndrome of hepatic and renal yin deficiency happens most frequently (49.5%), depression of liver-qi comes next (42.0%), Imbalance between heart-yang and kidney-yin occupies 8.6%, and the patterns of merely deficiency of kidney-yin and kidney-yang are 8.5%. There is no statistical significance in the syndrome patterns between post-menopausal and peri-menopausal patients (P>0.05).3. The constitutional symptoms which happen most frequenctly are as follows: hectic fever,pharyngoxerosis,insomnia,restlessness,forgetfulness,sore waist,anxiety,fatigue and etc. Symptoms of gynecology happen most frequently are as follows:menstrual disorder,hyposexuality,leucorrhea disorder and vagina abnormality. Hyposexuality and vagina abnormality in post-menopausal patients are more frequent than the peri-menopausal ones (P<0.05). 4. Kupperman scores of post-menopause patients is higher than the peri-menopausal ones. The disparity is statistically significant (p<0.05), which shows that the symptoms of the post-menopause patient is more serious than the peri-menopause ones, especially in insomnia,dizziness,fatigue and palpitation.5. The study also finds different kinds of symptoms in Climacteric Syndrome, including deprementia(50.7%),anxiety(83.7%),restlessness (85.2%),hyposexuality(55.0%),vagina abnormality(53.5%), which indicates that abnormal feeling and disharmony of the sexual life may be the key-point due to Climacteric Syndrome.6. There is statistical significance in scores of PF, RP,VT,RE,MH between post-menopausal and peri-menopausal patients (P>0.05). In the comparison, the scores of physical function,body role and energy of the peri-menopausal ones are higher than the post-menopausal ones, while the scores of sentimental role,mental health of the peri-menopause ones is lower. The results show that the living quality obviously steps down in the post-menopausal patients. The sentimental role,mental health of the peri-menopause ones is worse than the post-menopausal ones, that may because women are not adaptation when step into the menopausal period.