Flavored Soup Platycodon Effect On Mouse Model Of Slow Transit Constipation

Slow transit constipation is a clinically common functional intractable constipation, it’s main symptom is fewer defecate, no feeling of defecate and with abdominal distension, and the pathogenesis is not clear. The effect of Modern medicine conservative cure for STC is limited and the most serious situation is to cut the all colon, but the adhesion obstruction、diarrhea、 constipation recurrence are still bother the surgeon.According to the clinical symptom, STC is belong to the category of constipation in Chinese medicine, the famous historical doctors gradually developed a perfect theory, diagnosis and treatment to cure constipation with the long term clinical observation and practice. They knew that although the location is at large intestine, it also has much to do with the imbalance function of liver、spleen、kidney、lung and stomach. In Chinese medicine theory, especially guided by the theory of lung and large intestine, historical doctors got good performance in treating STC and also accumulated rich experience and got a new thinking way to cure this difficult disease. The lung disease transiting to large intestine and treating lung to cure large intestine disease are also according to "The lung and large intestine theory". We also can develop related research, represent the connotation of theory and explain the biology mechanism to improve "The lung and large intestine theory"With the research and theory discussion, our group design animal experiment to observe augmented Jie geng decoction, having influence on the STC mouse pattern, and to discuss the effect function of curing from lung to represent "The lung and large intestine theory’The First part of the literature researchReview Ⅰ:The modern medical study of STC can be coucluding:summed up the modern medical clinical presentation about STC, the reasons of the disease upset,related pathological mechanisms,the advances for the treatment and the reasearch propects...etc.Review Ⅱ:The study of in Chinese STC medical therapy progress:Review and summurize the Chinese medical causes and mechanisms,the treatment of the symdrom differenationmthe experimental study of STC’s the traditional chinese medical diagonsis and treatment,and it’s modern mechanism.Review III:Until now,the regular types about the sthenia-heat type,the cold accummulation type,the dry constipation type,the yin deficiency and blood stasis type,the weakness of the spleen,and the drug-induced constipation model were compared and summerized. To form the foundation to carry out the experimental research.The Second part of theoretical researchThe visicera-associated theory based on the traditional Chinese,especially "The lung associ-ated with large intestine"theory. combined with the six meridians disease treatment, using the methods of philology, constipation governance from the lungs on the ancient and modern litera-ture finishing the studies, including Treating the principle of the law of Treatment Recipe compat- ibility features for future clinical Treating constipation and related scientific research provides a theoretical basis.Third part experimental research40mice were randomly divided into normal control group, model group, treating group, and normal treating group. The mice model of constipation was established by using Compound Diphenoxylate. The model group and the normal control group were given intragastrically the distilled water, and other groups were given the Augmented Jiegeng Decoction(Jiegeng,Gan cao,Zi wan,and Bei mu) intragastrically for7days. Detecting transmission function of intestine, lung and intestine pathology,the promoting rate of ink,and the content of NKA,VIP,and TFF3in lung and intestine tissue.Results： Compared with the normal control group, the time of the first black feces, the faeces quantity within4hours, and the promoting rate of ink were significant difference in model group (P<0.01, or P<0.05); compared with the model group, there were significant improvement in treating group(P<0.05). The content of NKA in lung and intestine tissue is decreased obviously,and the content of VIP in lung tissue is increased obviously. Spearman simple correlation analysis shows that：There are significant correlations between the content of NKA,VIP,and TFF3.The Correlation coefficient are0.448,0.503,and0.423.The result suggested that,there is intestinal dysfunction of transmission in mice constipation model.The facilitating lung function of the Augmented Jiegeng Decoction can enhance the improving in transmission function of intestine in mice with constipation.The possible effect mechanism is regulating neuropeptides NKA,VIP in lung and intestine tissue.The result provide the evidence for further explore to"lung associated with large intestine theory"...