Through Belt Pulse Acupuncture Method Treatment Of Metabolic Syndrome Type Abdominal Obesity Effectiveness Research

Metabolic syndrome (MetS) is characterized by a cluster of cardiometabolic risk factors including obesity, hyperglycemia, atherogenic dyslipidemia, and hypertension. MetS represents a significant risk factor for the development of atherosclerotic cardiovascular disease (ASCVD), type2diabetes mellitus (T2DM), and stroke. It is estimated that around20%to25%of the world’s adult population have the MetS. MetS and its complications have become a relatively new chronic disease and public health problem.MetS’s core component is the frequently occurring abdominal obesity. The harm of abdominal obesity is visceral fat accumulated and hyperplasia of adipocytes. It could accelerate lipolysis, increase plasma free fatty acids, cause adipose ectopic deposition in non fat organs, inhibit glucose oxidated, promote gluconeogenesis and synthesis of low density lipoprotein (LDL) and very low density lipoprotein, down-regulate insul in receptors’number and affini ty at the membrane of the target cells, as well as increase adipokines and inflammatory mediators released by adipose tissue. Then the body signals adjustments were disordered, resulting in abnormal glucolipid metabolism and insulin resistance (IR). Hence, controlling abdominal obesity, which can prevent and treat MetS at the original state, is capable for a breakthrought point to studies for MetS.From past clinical work and studies, acupuncture has the certain advantages in the treatment of MetS and obesity. It reduces body mass index (BMI) and waist circumference (WC) effectively without adverse reaction, and improves the glucolipid metabolism disorders, thereby preventing cardiovascular events. There haven’t been studies in acupuncture for the influence of visceral adipose yet. This study within Chinese medicine and theory of pattern differentiation of meridians and collaterals, adpoted ultrasound detection of abdominal fat accumulation as the main outcome measure, accompanied simple anthropometric parameters and blood glucose, blood lipid, blood pressure, to investigate the influencing of acupuncture regulating Dai Meridian to the accumulation of abdominal adipose in abdominal obese patiets with MetS and the effects of regulating glucolipid metabolism disorders. It has important significance for definiting the effect of acupuncture regulating Dai Meridian for decreasing adipose accumulation, improving MetS, and preventing cardio-cerebro-vascular events.ObjectiveProspective studies, including an observational study and an experimental research, were uesd to observe the clinical efficacy of acupuncture for abdominal obesity on patients with MetS under the principle of regulation of Dai Meridian, furthermore to search his long-term effect.Methods1A prospective case series peviously collected80abdominal obesed patients with MetS met the inclusion criteria at the out-patient department of acupuncture and moxibustion, Dongfang Hospital, Beijing University of Chinese Medicine, who underwent treatment using the Dai meridian as the prime focus, to tentatively oberserve the clinial effect and long-term effect of this therapy.2According to the preliminary observation, an experimental research recruited40patients met met the inclusion criteria as the research objects, who were divided into acupuncture group and control group with20cases in each group, then compared the difference between acupuncture regulating Dai Meridian and blank control, to evaluate the clinical efficacy of acupuncture regulating Dai Meridian for abdominal obesity with MetS.Results1The observational study1.1Compliance:Out of80subjects,1of them was excluded due to an abnormal growth found in the abdomen during the ultrasound examination,14of them dropped out due to busy work, taking care of children or other diseases(such as osteoarthritis, fractures, renal calculi, and so on), and65of them completed the entire course. The compliance of this study was82.28%.1.2Short-term clinical effect:After treatment, the simple anthropometric parameters, thickness of abdominal subcutaneous and visceral adipose (S1, S2, V1, V2), antero-hepat ic fat (AHF) and perirenal fat (PRF), ultrasound viscerofatty index (UVI), fasting blood glucose (FBG), triglycerides (TG) and blood pressure were found to have decreased (P<0.001, P<0.05). Total cholesterol (TO level was lower, yet without statistical significance (P>0.05). High density lipoprotein (HDL) level were lower than pre-treatment (P<0.05). Low density lipoprotein (LDL) were increased after treatment, yet without statistical significance (P>0.05).1.3Long-term effect:At the3monthes follow-up, the simple anthropometric parameters, UVI, FBG, TG and blood pressure were in a declining trend (P<0.001, P<0.05). The thickness of S1, S2, AHF and RPF were decreased, but have a little rise compared with the end of treatment (P>0.05). TG and LDL levels hadn’t significant changed (P>0.05). While HDL decreased continuously (P<0.001).2The experimental research2.1Comparisons of simple anthropometric parameters:The simple anthropometric parameters of acupuncture group decreased after treatment (P<0.001), while they increased at control group (P<0.001, P<0.05). The effect of WC, waist-to-hip radio (WHR), and waist-to-height radio (WHtR) were better than control group (P<0.05). There were no differentiation in body mass, hip circumference (HC), BMI, and percentage of body fat (PBF) between two groups (P>0.05). However the differeces, calculated by subtract ing post-treatment value from pre-treatment one, had statistic differentiation between acupuncture group and control group (P<0.001).2.2Comparisons of thickness of abdominal adipose and UVI:The thickness of abdominal adipose and UVI of acupuncture group decreased after treatment (P<0.001, P<0.05). The S1, S2, V1, V2, and UVI had no difference at control group, while AHF and RPF increased (P<0.05, P<0.001). Comparisons between two groups after treatment, acunpuncture group was more effective than control group (P<0.05, P <0.001).2.3Comparisons of blood glucose, blood lipid and blood pressure:The results of blood tests at acupuncture group were the same as the observational study between pre-treatment and post-treatment. The TC, TG and LDL were found to have increased at control group (P<0.05, P <0.001), while HDL decreased (P<0.05). The FBG and blood pressure had no difference at control group (P>0.05). Comparisons between two groups after treatment, the improvement of FBG and TG at acunpuncture group was better than them at control group (P<0.05), while other outcomes were no difference (P>0.05). The differeces (pre-treatment minus post-treatment) of FBG, TC, TG and blood pressure had statistic different iat ion between acupuncture group and control group (P<0.001, P<0.05), except HDL (P>0.05).2.4Comparisons of the constituet ratio in criteria of MetS:The compl iance and improvement rates of WC, FBG, TG, HDL and diastol ic blood pressure (DBP) at acupuncture group were better than them at control group (P<0.001, P<0.05). Then the constituet ratio of systolic blood pressure (SBP) change was indifference (P>0.05).ConclusionAcupuncture on regulating Dai meridian has a significant short-term and long term effect on the WC, WHR, WHtR and the thickness of abdominal adipose, UVI, as well as FBG and TG of abdominal obesed patients with MetS. Meanwhile, acupuncture on regulating Dai meridian could improve body mass, HC, PBF, and TC, blood pressure levels in a certain extent, relieve the aggravating trend of MetS, increase the compliance rates of criteria of MetS. That is positive significance for prevention and treatment of MetS and cardio-cerebro-vascular diseases.