Papillary Throid Cancer With Benign Thyroid Diseases:Clinical Manifestation And Prognosis

Objective:To analyze the epidemiological features of thyroid carcinoma in patients from Union Hospital of Huazhong University of Science and Tecnology in last7yearsMethods:Records of1647patients with thyroid carcinoma, who underwent thyroidectomy and pathological examination, were reviewed from January2006to December2012.Results:(1)Patients that suffered thyroid cancer have increased rapidly during these7years.(2)The high incidence of the disease located in the age group of40-44years old for men and45-59years old for women, with a male-to-female ratio of1:3.87.Conclusion:The occurrence of thyroid carcinoma, especially papillary carcinoma has been increasing in recent years. Objective:The aim of this study was to evaluate the clinicopathologic characteristics of papillary thyroid cancer with chronic Hashitomo’s thyroiditis, and to evaluate the prognostic outcomeMethods:A retrospective review of patients with thyroid carcinoma who underwent primary throidectomy was performed. Devide those patients into two groups.Group A had Hashimoto’s thyroiditis; Group B had no Hashimoto’s thyroiditis. Compare the clinicopathologic results of two groups and proceed statistical analysis.Results:1.Among928patients, there were180male patients and748female patients. The average age was42.51±11.70yr. The mean tumor size was1.39±0.88cm(evaluated by the biggest tumor size for multifocality). Among all these patients,there were316patients with multifocality, for34.05%;244patients with extrathyroidal extension, for26.29%;478patients with central LN metastasis,for51.51%and180patients with Hashimoto’s thyroiditis. The average age of Group A was41.1±11.44yr and42.85±11.81yr in Group B. The proportion of female in Group A was greater than Group B. The maximum tumor size of Group A was1.29±0.77cm, that in Group B was1.42±1.01cm. The proportion of central LN metastasis and extrathyroidal extension were also lower in Group A. The TSH level before surgery was3.33±2.70in Group A and1.87±1.51in Group B.2.Evaluation of expected prognostic outcome using AMES clinical staging system and the MACIS scoring system. With the AMES system, the proportion of high-risk group of patients without Hashimoto’s thyroiditis was higher than that of patients with it. Using the MACIS scoring system, the proportion of high-risk group of patients without Hashimoto’s thyroiditis was also higher than the other group.3. We evaluated the patients of papillary thyroid cancer coexisting with Hashimoto’s thyroiditis between pathologic diagnostic and laboratory finding.Conclusions:1.The prevalence of females was higher in papillary thyroid cancer patients that with Hashimoto’s thyroidtitis than without Hashimoto’s thyroidtitis.2.The papillary thyroid cancer patients with Hashimoto’s thyroiditis had low risk of expected prognostic than without Hashimoto’s thyroiditis.There is no statistically significant difference in gender, size, prevalence of extrathyroidal extension, multifocality, LN metastasis and TNM stage.But the age of patients in Group I (antibodies were negative) was older than Group Ⅱ. Objective:The aim of this study was to evaluate the clinicopathologic characteristics of papillary thyroid cancer with nodular goiter, and to evaluate the prognostic outcomeMethods:A retrospective review of patients with thyroid carcinoma who underwent primary throidectomy was performed. Devide those patients into two groups.Group A had nodular goiter;Group B had no nodular goiter. Compare the clinicopathologic results of two groups and proceed statistical analysis.Results:1.Among928patients, there were180male patients and748female patients. The average age was42.51+11.70yr. The mean tumor size was1.39±0.88cm(evaluated by the biggest tumor size for multifocality). Among all these patients,there were316patients with multifocality, for34.05%;244patients with extrathyroidal extension, for26.29%;478patients with central LN metastasis,for51.51%and364patients with Nodular goiter. The average age of Group A was48.45±11.26yr and38.68±10.40yr in Group B. The proportion of female in Group A was greater than Group B. The maximum tumor size of Group A was1.00±0.75cm, that in Group B was1.65±1.10cm. The proportion of central LN metastasis and extrathyroidal extension were also lower in Group A.2.Evaluation of expected prognostic outcome using AMES clinical staging system and the MACIS scoring system. With the AMES system, the proportion of high-risk group of patients without nodular goiter was higher than that of patients with it. Using the MACIS scoring system, the proportion of high-risk group of patients without nodular goiter was also higher than the other group.Conclusions:1.The prevalence of females was higher in papillary thyroid cancer patients that with nodular goiter than without it and the former had smaller tumor size than the latter. And the PTC without nodular goiter had more chance for central LN metastasis and multifocality.2.The papillary thyroid cancer patients with nodular goiter had low risk of expected prognostic than without nodular goiter.