Clinical Research Of Hejiefenxiaotang On Acute Kidney Injury Shi-re Syndrome

ObjectiveTo evaluate the clinical effect of Hejiefenxiao Tang on AKI (acute kidney injury) Shi-re patients; and long-term effect of Hejiefenxiao Tang on renal function.MethodsA single center, prospective, parallel control study design was carried out. Patients diagnosed by nephrologists came from the inpatients of Guang’anmen Hospital from February 2012 to February 2014.35 in treatment group and 42 in control group. Both groups were given treatments such as elimination of the incentives, symptomatic treatment and supportive treatment; besides, the treatment group accepted Hejiefenxiao Tang for 14 days. Taking end stage renal disease, maintenance of hemodialysis and death as clinical end-points. Data was analyzed by SPSS 16.0 statistical package.Results1. General material and baseline comparison There were 49 men and 28 women. The average age was 58.01±19.992. There weren’t any significant differences in indexes of age, sex, acute kidney injury causes, chronic diseases, serum creatinine (SCr)、blood urine nitrogen (BUN)、evaluated glomerular filtration rate (eGFR)、uric acid (UA)、albumin (ALB), integral of Shi-re syndrome of both groups when enrolled (p>0.05)2 Clinical effects after 14 days’treatmentIn the treatment group,SCr、UA、BUN were decreased, eGFR was increased (p<0.05). While in the control group, SCr、UA were decreased, the eGFR was increased (p<0.05).Both groups could decrease the interal of Shi-re syndrome; there was’t any differences between them.Both groups could decrease the interal of TCM syndrome; the treatment group was better in improving AKI patients’clinical symptoms.There weren’t any differences in renal function recovery ratio, survival ratio, clinical end-points ratio and renal replacement ratio (p>0.05)3 Follow-up results3.130 days’follow-up resultsSignificant differences appeared in renal function recovery ratio, survival ratio, clinical end-points ratio and renal replacement ratio (p<0.05)3.2 90 days’follow-up resultsThere were still significant differences in renal function recovery ratio, survival ratio, clinical end-points ratio and renal replacement ratio (p<0.05)3.3 180 days’ follow-up resultsSignificant differences existed in renal function recovery ratio, survival ratio, and clinical end-points ratio (p<0.05); but disappeared in renal replacement ratio (p> 0.05).4 Analysis of factors correlated with renal function recoveryMulti-factors analysis showed that TCM interfering was good for the recovery of renal function; the higher the integral of TCM syndrome enrolling, the less recovery of renal function.5 Analysis of Cox proportional hazard modelResults showed that only group, CKD, lung diseases, inflammation, SCr and ALB enrolled were risk factors of the prognosis.Conclusions1 There was advantage of Hejiefenxiao Tang in improving patients’interal of TCM syndrome.2 After 14 days’treatment, differences of clinical effect in renal function recovery ratio, survival ratio, and clinical end-points ratio existed from day 30 to 180; difference in renal replacement ratio existes from day 30 to 90.3 Hejiefenxiao Tang was not only influencing factor of renal function recovery, but also influencing factor of clinical endpoints.