| Objective:To observe the effects of 15-amino acid intra-operative infusion on glucose and fat metabolism and temperature changes in patients with GI tumors undergoing elective surgeries.Methods:40 patients (ASAI-Ⅱ) scheduled for fast gastro-intestinal surgeries were included in this study and randomly divided into the control group and the 15-amino acid (15-aa) group. Infusion of Ringer’s or 6.9% 15-aa 3.4ml/kg/h, depending on the groups, was initiated from the start till the end of the surgeries. Parameters including HR, BP, SPO2, PCO2, MAC, and pharyngeal temperature were recorded during surgeries. Glucose levels, serum insulin levels, serum ketone bodies levels, and serum free fatty acid levels were measured 30 minutes before induction of general anesthesia (TO), right after induction of anesthesia (T1),30 minutes after surgeries began (T2), two hours into surgeries (T3) and one hour after surgeries (T4), respectively.Results:(1) As the surgeries proceeded, body temperatures tended to decrease significantly (P<0.05) and rebound at T4. The body temperatures did not have significant differences between the 15-aa group and the control group in whole, as well as at any time during the experiment. (2) The glucose levels of 15-aa group (7.46 ±1.28mmol/L) was significantly higher than the control group (5.86±2.12mmol/L) at T3 (P<0.05). (3) The insulin level of the 15-aa group was significantly higher than the control group at T3 and T4 (P<0.05). (4) The ketone bodies levels of the 15-aa group was significantly lower than the control group at T3 and T4 (P<0.05). (5) The free fatty acid levels in the 15-aa group had a lower free fatty acid level at T1 (P<0.05), T2 (P<0.05), and T4 (P<0.05).Conclusion:Intra-operative infusion of 15-amino acid suppressed fat mobilization and mildly elevated serum glucose level, but had limited thermogenesis. |
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