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Establishment Of The Digital Three-dimensional Assessment Platform Of Locally Advanced Cervical Cancer For Accurate Neoadjuvant Inter-arterial Chemotherapy

Posted on:2014-04-29Degree:DoctorType:Dissertation
Country:ChinaCandidate:C L ChenFull Text:PDF
GTID:1224330467984842Subject:Human Anatomy and Embryology
Abstract/Summary:PDF Full Text Request
Locally advanced cervical cancer (Locally Advanced Cervical Cancer, LACC) is a cervical cancer of the high-risk factors, in a broad sense it refers to the stage I B~IV A cervical cancer, narrowly foci diameter>4cm early cervical cancer (Phase I B2, II A2period). The huge local tumor and/or extensive infiltration of the surrounding tissue is characterized as the main reason for its poor prognosis. LACC cases accounted for70%n the first treatment, surgery alone or radiotherapy, the five-year survival rate is only50%, and how to improve the efficacy is one of the issues we need to address. Lots of researchs proved that can preoperative neoadjuvant chemotherapy and surgical treatment is an effective method to improve the LACC efficacy. Neoadjuvant chemotherapy with intravenous chemotherapy and arterial chemotherapy, studies show that the LACC cases underwent preoperative neoadjuvant intra-arterial chemotherapy, anticancer drugs in cancer tissue concentration, total or clinical efficacy superior to intravenous chemotherapy. Although the clinical efficacy of intra-arterial chemotherapy is significant, there is still part of the cases fail to get the ideal results, in addition to the common factors of the biological characteristics of the tumor, the sensitivity of anti-cancer drugs, but also the distribution of anti-cancer drugs within the foci and effective dose clinicians arterial chemotherapy the LACC foci of the blood for the lack of a detailed understanding of result in the foci drug uneven distribution is one of the important reasons. As for arterial chemotherapy anti-cancer drug concentration-dependent, the reasonable allocation of arterial chemotherapy anticancer drugs in tumor feeding artery is closely related. But LACC arterial chemotherapy, preoperative unsure of the foci of the blood supply, either assigned perfusion arteries choice or anti-cancer drugs often have clinical experience which is mainly larger subjectivity and randomness, influence the efficacy of the further improved. If we can clear the blood supply to the cervical cancer foci characteristics before arterial chemotherapy:the source of the feeding artery, the number of blood supply type, foci within the total blood volume, blood flow richness and artery ratio, based on the preoperative develop appropriate plans to guide the rational allocation of operative and anti-cancer drugs, will be conducive to further improve the implementation and efficacy of intra-arterial chemotherapy. Therefore, the research of LACC foci arterial blood supply is essential.This study first retrospective analysis summarizes LACC digital subtraction angiography (Digital Subtraction Angiography, DSA) image, and comparative analysis of the classification of the feeding arteries sources, blood type and blood flow richness to understand the LACC blood under the DSA supply features; then reconstructed the normal uterine arteries digitized three-dimensional model,analysis the anatomical features of the vascular net work and the blood supply characteristic; and then reconstructed a cervical cancer in vitro uterine artery vascular network of blood for characteristics;and further using digitied three-dimensional reconstruction of the building based on CT vascular imaging (CT angiography, CTA) data sets LACC foci in systemic arterial vascular networks digitized three-dimensional model and its corresponding DSA images relative comparison, to understand the building model with DSA was developing vascular consistency. Further analysis of the application of computer software based on the characteristics of blood supply of LACC number of clear foci in arterial chemotherapy before surgery that the sources of the feeding arteries, blood type, blood flow richness and accurate calculation of the total blood volume within the foci each artery proportion. The purpose of this study is to get the rational allocation of operative arterial chemotherapy and anti-cancer drugs the vascular anatomical basis and to reach preoperative anatomic reality, the operation of precise treatment. Part I Characteristics of vascular supply to locally advanced cervical cancer base on digital subtraction angiography[Objective]To investigate the characteristics of vascular supply to locally advanced cervical cancer base on digital subtraction angiography and instruct the clinical application.[Material and methods]A total of67consecutive patients with LACC were treated by arterial infusion or embolism chemotherapy from January2005to December2012at two independent institutions:southern medical hospital, Guangzhou No.1People’s Hospital. The DSA datas of them were obtained. The internal iliac arteriography or uterine arteriography was performed according to Seldinger’s technique. DSA angiograph of bilateral uterine artery was obtained. The collection of images and pictures are engraved plate to save. Import DSA images collected in the same arterial phase to Photoshop software, and register by using intrauterine contraceptive ring, the arterial sheath tube or silver clip as a registration point. Import and save images as JPG format.[Results]1、The main feeding arteries of LACCIn our study, the uterine artery fed all of LACC, and mainly to the descending branch of uterine artery. The vaginal artery in the blood supply was visualized in one patient when internal iliac artery angiography.2、The characteristics and grades of LACCThe LACC vascularity was categorised as four types. The major type was hypervascular, accounting for61.19%(41/67) of cases; this was followed by isovascular and hypovascular types, accounting for20.90%(14/67),17.91%(12/67) of cases respectively.3、The types of LACC vascular supply The vascular supply to LACC was classified as four types according to the predominant vessel branches and their supporting ratio. Except for one cases, the LACC were hypovascular and could not identify the lesion, we demonstrated that type II (unilateral predominant) was the most common type, accounting for52.72%(29/55) of all cases. This was followed by type I (bilateral balanced), accounting for41.82%(23/55) of cases. Unilateral uterine arteries supplying the LACC singly (type III) were found in6cases, accounting for5.45%(3/55) of cases.[Discussion]Our study demonstrated that LACC was supplied by bilateral uterine arteries,and the vaginal artery or other arteries were also in the blood supply by the analysis on the classification of vascular supply and the grades of vascularity in LACC Based on DSA images. Unilateral predominant was the most common type and less unilateral uterine arteries supplying the LACC singly in the type of LACC vascular supply. The major type was hypervascular, followed by is ovascular types, while the hypovascular types was the most rare types, which laid an anatomical and morphological basis for individualized clinical arterial perfusion/chemoembolization. Part II Characteristics of vascular supply to digitized three-dimensional model of normal uterus[Objective]To construct a model of the uterine vascular supply through vascular casting and thin slice computed tomography scanning and investigate the characteristics of vascular supply.[Materials and Methods]We recruit a total of25normal female volunteers and collected CTA original data set through August2012to December2012. All volunteers had no history of pregnancy, surgical history, and history of allergies, excluded by B-ultrasound abdominal and pelvic disease of the uterus and two annexes, signed related informed consent.All the25normal female volunteers scanned under the64slice spiral CT (SOMATOM Definition). The application of contrast agent tracer method CTA scan and capture images of each period. Mimics software by automatic positioning images, organize pictures within the interpolation process the threshold growth step, to build the uterine artery vascular network digital three-dimensional model, clear uterine source and quantity of the various parts of the feeding artery. Mimics software, three-dimensional cutting into the uterine artery vascular network model Palace/cervical arterial vascular network, left/right side of the Palace of the arterial vascular network, left/right cervical artery vascular network, left/right ovarian artery network and to calculate the proportion of blood volume and blood supply.[Results]Based on CTA scanning technology and digital three-dimensional reconstruction techniques, this study successfully constructed25normal women uterine artery vascular network digital three-dimensional model, these models clearly shows the uterine artery and its branch structure at all levels.25cases of the model clearly show the uterine artery ascending branch of uterine artery issued in the mouth of the cervix level, only two cases of model developing uterine artery descending branch. Compared with the other branches ascending branch of uterine artery are thick, issued along the arcuate artery in the upstream process, and further issued a number of spiral arteries supply the muscles of the body of the uterus and endometrium; the upstream branch at the bottom of the uterus, not only issue palace at the end support outside, but also issue the ovarian branch and fallopian tubes branches supply the ovaries and fallopian tubes; ovarian branch of the uterine artery, tubal branch of the ovarian artery together constitute the supply of ovaries and fallopian tubes annular arterial vascular network. Descending branch is smaller, which offer the main supply of blood to the cervix. Uterine arteries that supply blood to the ipsilateral uterine anastomosis is formed at the central axis of the uterus, and the traffic branch is smaller. Palace vascular network is clear, rich, but the cervical vascular network is not obvious.25normal female uterine artery vascular network digital three-dimensional model of the Palace proportion of the blood supply on the left and the Palace of the right side portion of the proportion of blood supply Levene’s variance test of homogeneity of both homogeneity of variance (F=0.001, P=0.971). Through statistics, the comparison between proportion of the left side of the palace and the right side of the palace, the difference was not statistically significant (t=1.817, P=0.077).[Discussion]By observing the normal female found in the the uterine arteries digital three-dimensional model:the uterus are supplied by bilateral balance uterine artery; ascending branch of the uterine artery are thick, part of Palace have rich blood supply, the uterine artery ascendant branch in the womb axis by a small number of trafficsupport and coincide with each other; descending branch of the uterine artery are small, the cervical vascular network is not obvious, the cervical proportion of blood supply is very few in the entire uterus. The digital three-dimensional model of the uterine arteries in normal women provide anatomical basis, and provides a theoretical basis for the diagnosis and treatment of diseases in obstetrics and gynecology. Part III The characteristics of blood supply of digital three-dimensional model of uterine arterial vascular network in vitro of cervical cancer through vascular casting and CT data[Objective]To construct a model of uterine arterial vascular network in vitro of cervical cancer through vascular casting and thin slice computed tomography scanning and investigate the characteristics of blood supply.[Materials and Methods]One sets of specimen were collected by the Department of Anatomy, Southern Medical University. Snip pelvic funnel ligament, cardinal ligament, broad ligament, uteosacral ligament of uterus close to the pelvic wall. Intercept the uterus, vaginas and bilateral adnexa completely. Retain uterine artery, ovarian artery stump as long as enough. By examining the specimens found the cauliflower-like tumor, cervical cancer lesions was confirmed by biopsy. Separate the uterine artery, select the appropriate caliber glass cannula to insert, fix them with ligatures, put the uterus specimens in a special container and simulate normal anatomic position,then using64-slice CT scanner produced by Philips for thin layer scanning and collecting original data set, connected to the plastic syringe filled with red fillers, and then use the homemade pressure, poured the already configured perfusion fluid of20%concentration from the uterine artery, to obtain the original CT scan data set again. Reperfused specimens were put in a37%solution of hydrochloric acid for corrosion, to obtain the model of cervical uterine artery vascular network in vitro. Based on the CT data sets and by using Mimics software we can built cervical cancer uterine artery vascular network model in vitro, and further use of surface cutting and wire cutting tools, uterine artery vascular network model plane by the mouth of the cervix and uterus axis along the traffic anastomosis sparse, small part of a three-dimensional segmentation, to calculate the blood volume and blood in proportion to the allocation of the parts of the model.[Results]1、The CT scan characteristics before and after uterine perfusion in uterine arterial vascular network in vitro of cervical cancerThe CT scan images showed homogeneous low density before perfusion, without obvious abnormal density shadow, we still cannot distinguish the arteries from the images. There is no significant change of the uterus soft tissue shadow in CT scan images after perfusion, but the arteries in the tissue were enhanced presented high density shadow, the arteries are full and those shape are regular, showed a stark contrast with adjacent soft tissue.2、The characteristics of the uterine arterial vascular network in vitro of cervical cancerThe digital model clearly showed the arterial vascular network of uterine body and cervix uterus. Distribution of the blood supply of the cervical cancer lesions:The blood supply of the cervical cancer lesions is mainly from the uterine artery descending branch, its blood supply range exceeds the normal cervical and partial upper vagina, and stretch to the left parametrial. The blood supply is mainly from one side, but there is traffic branch to the contralateral. The blood supply of the cancer lesions is rich, the vascular is disorganized, show irregular thickening. It is obvious lack of the local vascular at the cesarean section scar which is at the lower section of the anterior wall of the uterus, exist2.0cm×1.5cm avascular zone.3、The characteristics of vascular supply of the uterine arterial vascular network in vitro of cervical cancerAs the model of uterine arterial vascular network in vitro of cervical cancer, cervical cancer uterine arteries digital three-dimensional model based on the the vascular the cast specimens technology and the CT scan data set can clearly shows the trunk of the origin of uterine artery and vascular network of branch distribution in all levels, main blood supply of the foci originated in the left uterine artery and the foci is rich in blood and blood vessel disorders. However, compared with the cast specimens from the body cervical uterine artery vascular network, we can observe the digital three-dimensional model in three-dimensional version, and can also edit digital picture mode for many people at the same time. Additionally, you can split and calculate digital three-dimensional model of the arterial vascular network of cervical cancer in vitro by using computer software. Through the blood volume calculation of the three digital three-dimensional models for arterial network of cervical cancer, we found that:The total blood volume of the uterus was30.11ml. The blood volume of corpus uteri and cervix uteri were21.87ml and6.32ml, accounted for the total arterial blood volume of about72.63%and20.99%respectively. The blood volume of left part and right part of cervix uterus were4.10ml and2.22ml, accounted for the total cervix uteri blood volume of about64.87%and35.13%respectively. The blood volume of the corpus uteri is3.46times of cervix uteri, and bilateral uterine artery blood supply to the cervical cancer lesions exists obvious "imbalance".[Discussion]The model of the uterine vascular supply can be successfully reconstructed by vascular casting and thin slice CT scanning. Using the digital three-dimensional reconstruction and three-dimensional segmentation tools in Mimics3D software, we found that the Blood supply by Uterine artery of Cervical cancer lesions is generally unilateral, and based on this, we can create reconstructions as well as models for Cervical cancer in vivio through thin slice computed tomography scanning. Part IV The establishment of digital three-dimensional evaluation platform of accurate preoperative chemotherapy in locally advanced cervical cancerChapter1The contrast of CTA based the blood supply of digitial three-dimensional model of the arterial vascular network with DSA images in locally advanced cervical cancer[Objective]To explore the consistency by comparing the digital three-dimensional model of the LACC arterial vascular network in vivo with the images of DSA angiography images.[Materials and Methods]Selected20patients with locally advanced cervical cancer who underwent preoperative neoadjuvant arterial chemotherapy in Nanfang Hospital of Southern Medical University between September2010and May2011. All patients were excluded Cardiovascular disease, hyperthyroidism, pregnancy, had no history of drugs and seafood allergy, accepted preoperative neoadjuvant intra-arterial chemotherapy after informed the efficacy and risks of arterial chemotherapy and other alternative treatment protocols, and received preoperative CTA, and signed informed consent.Used dual-source CT produced by the German company Siemens, ultravist and binoculars high-pressure syringe. CT scanning were performed according by bolus tracking, After that, we obtained the data of the image of every phases.Construction of digital three-dimensional model of pelvic and arterial vascular network in locally advanced cervical cancer in vivo through automatic positioning images, organizing photos and interpolation processing by using Mimics software. All patients were confirmed by angiography of the internal iliac artery and uterine artery angiography in arterial chemotherapy operation by using Seldinger’s technique. We collected images and pictures and engraved CD to save. We imported the the same arterial phase DSA image into Photoshop, true up the picture by a registration point such as intrauterine contraceptive ring, arterial sheath, silver clip or pelvis and other fixed or special signs. At last, we export the images as JPG format to save.According to the LACC foci of arterial vascular network digital three-dimensional models and types of blood supply of the the LACC DSA image classification criteria, we can classify the LACC foci blood supply into bilateral balance type, the main side of blood supply and separate side for blood type. Similarly, according to the richness of the blood supply of the LACC foci arterial digital three-dimensional model and the LACC DSA image blood flow classification criteria, the foci is divided into rich blood type, blood type and lack of blood flow type respectively.[Results]1、characteristics of digital three-dimensional models of the artery vascular network in cervical cancerBased on the original CTA datasets, we use Mimics three-dimensional reconstruction software, successfully constructed20digital three-dimensional models of arterial vascular network in locally advanced cervical cancer, which truely reconstruction all levels of abdominal and pelvic arteries. The models not only can provide an arbitrary rotation and size scaling, but also can achieve random cutting and separation of the model using Mimics software,to observe the shape and distribution of the pelvic artery and features of the vascular network of the uterine artery, the tumor feeding artery and blood supply. 2、Compared digital three-dimensional model of the feed-artery in cervical cancer with DSA imagesCompared20angiographic images with the developing situation of digital three-dimensional model of the feeding artery, there was no statistically significant difference, both showed the tumor feeding artery not only from the uterine artery, and in some cases, vaginal artery pudendal artery is also involved in the blood supply to the tumor. But to the arteries which can be displayed in digital three-dimensional model of LACC arteries in body or the arteries which can not be displayed in uterine artery angiography, there was no statistically significant difference (x2=2.57, P=0.28).3、Compared digital three-dimensional model of the type of cervical arteries network in cervical cancer with DSABody cervical arteries digitized three-dimensional model of the type of blood supply with the DSA image contrast, the difference was not statistically significant (X2=3.179, P=0.199).4、The comparison of blood richness between LACC foci of arterial vascular network digital three-dimensional model and DSA imagesCompared with DSA images blood richness in the body cervical arteries digital three-dimensional model, the type of tumor blood supply can mainly be divided into rich blood type and blood type, no lack of blood flow, there was no statistically significant (x2=0.071, P=0.750).[Discussion]By CTA based computer three-dimensional reconstruction techniques, compared with DSA images, it has high similarity. In turn, taking DSA images as the standard, we can optimize the construction of three-dimensional model of the arterial vascular network in locally advanced cervical cancer, so as to provide a platform to truly realize clinical personalized assessment and treatment of patients with cervical cancer. Chapter2The establishment of digital three-dimensional evaluation platform of accurate preoperative chemotherapy in locally advanced cervical cancer[Objective]To establish the accurate LACC preoperative arterial chemotherapy digital three-dimensional evaluation platform by analyzing the sources of feeding arteries, the type of blood supply and the blood flow richness of LACC arterial vascular network in the digital three-dimensional model.[Materials and Methods]49patients with locally advanced cervical cancer who underwent preoperative neoadjuvant arterial chemotherapy in Nanfang Hospital of Southern Medical University between September2010and February2013. All patients were excluded Cardiovascular disease, hyperthyroidism, pregnancy, had no history of drugs and seafood allergy, accepted preoperative neoadjuvant intra-arterial chemotherapy after informed the efficacy and risks of arterial chemotherapy and other alternative treatment protocols, and received preoperative CTA, and signed informed consent.Used dual-source CT produced by the German company Siemens, ultravist and binoculars high-pressure syringe. CT scanning were performed according by bolus tracking, After that, we obtained the data of the image of every phases. Reconstruct the digital three-dimensional model of pelvic and arterial vascular network in locally advanced cervical cancer in vivo through automatic positioning images, organizing photos and interpolation processing by using Mimics software. Making use of cutting tools and wire-cutting tools of the Mimics software’s to cutting uterine artery network model, divided it into the Palace/cervical artery network, left/right side of the Palace arterial vascular network, left/right side of the cervical arteries network, then calculated the blood-volume of each divided portion. particularly cervical cancer foci parts.Quantitative comparisons the cervical blood volume and the Palace of blood volume based on digitized three-dimensional model of the LACC arterial vascular network, the model is divided into hypervascular, isovascular and hypovascular. The quantitative analysis of blood volume and proportion of blood distribution on the left/right side of the copus and left/right side of the cervical, the models were divided into the type of bilateral balanced, unilateral predominant and ipsilateral. The type of unilateral predominant and ipsilateral were separate the left side for the blood type, separate the right side for the blood type for blood type and the right side of the left side of the main primary for blood type according to the model characteristics.By comparing LACC foci arterial digital three-dimensional model in vivo with the second part of uterine arteries digital three-dimensional model in normal women from feeding arteries sources, types of blood supply and richness of blood flow,we can get the features.[Results]1、the sources of arteries supplied to locally advanced cervicalObserving49models, we could see the arteries that supplied carcinoma mainly comes from the bilateral uterine arteries, the vaginal artery and pudendal artery also involved with carcinoma increased. Within49cases,11(22.44%) models showed vaginal artery involved,2models showed pudendal artery involved, which contained4patients of IB2,5patients of IIA2,2patients of IIB. In addition, six(12.24%) models showed than the ovarian arterial supply to the uterus,3(6.12%) models showed the formation of arteriovenous fistula,with the ovarian vein visible.2、blood flow richness in digital three-dimensional model of the the LACC foci of arterial vascular network of tumor Based on the classification criteria,49patients with LACC foci arterial digital three-dimensional model, rich blood type accounted for61.22%(30/49),32.65%of the normal blood flow (16/49),6.12%of the lack of blood flow type (3/49).3、the analysis of blood supply characteristics and proportion(1) the analysis of blood supply characteristics and proportion.By observing49digital three-dimensional models in vivo for arterial network of locally advanced cervical cancer,we found that bilateral balanced account for39.13%(18/46), unilateral predominant account for34.78%(16/46) and ipsilateral account for26.09%(12/46)(2).the locally advanced cervical cancer with different stageBy observing49digital three-dimensional models in vivo for arterial network of locally advanced cervical cancer,we found that there was no difference between type of bilateral balanced, unilateral predominant and ipsilateral., the difference existed no statistical significance (t=8.86, P=0.194).The proportion was as follows:compared with the corpus and cervical, the difference was not statistically significant (P=0.641, P=0.641).While compared with IB2、IIA2and IIB the difference was not statistically significant(P=0.413,P=0.125and P=0.963).(3).the comparison of different type of blood supply to the left/right side of the blood supply to the proportion of digital three-dimensional model of the the LACC foci of arterial vascular network of cervicalOne side for blood group foci only by the side of the uterine artery or other blood supply to the branch, while the other three different type of blood supply of the LACC foci of arterial vascular network in the three-dimensional digitized model, the left portion of the cervical blood supply ratio and the right of the cervix in the proportion of blood supply by the homogeneity of variance test results suggest that both homogeneity of variance (P=1.000).In the bilateral balanced,compared the left side of the cervical blood supply to the ratio of the proportion of blood supply with the right side of the cervix, the difference was not statistically significant (t=0.518, P=0.608), but the blood flow to the left side of the main type and to the right side predominant, compared the cervical blood supply ratio, the differences were statistically significant (t=10.700, P<0.01). The left side of the three different types of blood supply LACC cervical blood supply compared to the proportion of the difference was statistically significant (F=81.981, P0.01) Similarly, the proportion of the right side of the cervical blood supply compared, the difference was statistically significant (F=81.984, P<0.01). By LSD-t test further pairwise comparisons (P<0.01) differences were statistically significant.(4). Different types of blood supplyType IV did not display the carcinoma. Separate side of the blood type can be judged to left side alone and right side alone according to the characteristic of the model. In the four type,there was no statistically significant whether the blood supply of palace came from left or right(r=0.438, P=0.008).4., The comparison between LACC foci arterial vascular network three-dimensional digital model and three-dimensional digital model of the uterine artery vascular network in normal womenThe comparison between LACC foci arterial vascular network three-dimensional digital model and three-dimensional digital model of the uterine artery vascular network in normal women shows both the palace of the feeding arteries are uterine artery ascending branch, and the palace clear vascular network was bilateral and balanced. The cervical vascular network in the uterine artery vascular network digital three-dimensional model of the normal woman is almost transparent. Palace and cervical blood supply ratio of1:0, but the in LACC foci of arterial vascular network digital three-dimensional model, we found the cervix sources of feeding arteries came from not only the descending branch of the uterine artery, but also from the vaginal artery or pudendal artery. The vascular network is rich, blood supply is uneven, the palace and cervical blood supply ratio is about1:1.[Discussion]Constructed locally advanced cervical cancer foci in digital three-dimensional model of the systemic arterial vascular network, the model built for the use of the patient’s state of calm CTA scan data set using digital three-dimensional reconstruction of its vascular development without additional pressure, vascular network morphology as the physiological state. Body locally advanced cervical arteries digitized three-dimensional model can fully reflect the characteristics of the patients foci feeding artery anatomy and blood supply in proportion to the allocation of patients with locally advanced cervical cancer, on this basis, according to the anatomical individualized characteristics " individualized treatment to reduce patients and doctors ray exposure rate, shorten the operation time and enhancing foci drug concentration to avoid medical waste. Summary1. In this study, by retrospectively analyzing the DSA information of67cases of LACC, we found that the blood supply of LACC mainly from the uterine artery, only1case also from vaginal artery; The main blood supply types of the foci are bilateral balanced type and unilateral predominant type, andsingle one side for blood supply is rare. The to the richness of the foci blood flow are more common in the hypervascular type, followed by the isovascular type, the hypovascular type is rare,2. In this study, by constructing25cases of uterine artery network of digitized three-dimensional model in normal women, we understand the anatomical structure of artery vascular network and blood distribution characteristics in normal uterus uterine, and by using the Mimics software, we carried out three-dimensional segmentation on the various parts of the uterus, and calculated the proportion of branches of uterine arteries in normal uterine blood distribution. Thus we found normal uterine artery vascular network has the characteristics of bilateral, ipsilateral blood supply tendentious and balanced and the cervical vascular network developing low.3. We got one uterus specimens suffered cervical cancer in vitro, and then obtained the digital three-dimensional reconstruction model by using Mimics3D software and analyzed three-dimensional segmentation. And we found Palace cervical blood for the proportion of3.46:1Arterial vascular network in the body of digitized three-dimensional reconstruction of cervical cancer provide anatomical basis for the clinical use of thin-section CT enhanced scan.4. By constructing cervical arteries digital three-dimensional model in vivo and comparing with the DSA image,we found cervical arterial network digital three-dimensional model in vivo and DSA images has a high degree of similarity. However, compared with DSA image, the cervical arteries digital three-dimensional model in vivo is to better guide the implementation...
Keywords/Search Tags:locally advanced cervical cancer, arterial chemotherapy, digitized, three-dimensional model, clinics platform, evaluate
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