| PART 110-YEAR VARIANT PREVALENCE OF DIABETES AND PRE-DIABETES IN A COMMUNITY OF CHONGQINGObjective:To estimate the variances of prevalence of diabetes and pre-diabetes in a community of Chongqing in recent 10 years.Methods:The surveys were conducted in year 2003,2008, and 2013 respectively. All patients underwent anthropometric measurements and oral glucose tolerance test (OGTT). Subjects were diagnosed as diabetes or pre-diabetes according to the World Health Organization (WHO) criteria 1999.Results:A total of 3140,3867,5429 participants were recruited in year 2003,2008,2013 respectively. There was no significant difference in age, BMI, or waist circumference among the subjects. The age-standardized prevalence of diabetes was 8.9%,13.3% and 19.2% respectively, and the age-standardized prevalence of pre-diabetes was 15.6%,16.91% and 28.9% respectively. The prevalence of diabetes and the rate of increase were higher among men than that among women. In addition, the prevalence of diabetes had a growing tendency with ageing.Conclusion:There was a significant increase in the prevalence of diabetes and pre-diabetes in this community of Chongqing over the recent 10 years. Diabetes has become a major public health problem that more prevention and treatment are needed. PART 2 THE EFFECT OF SERUM COMPLEMENT 3 ON PREDICTION OF TYPE 2 DIABETES MELLITUSObjective:To investigate whether elevated levels of serum complement factor 3 (C3) increase the risk of developing type 2 diabetes mellitus (T2DM).Methods:This was a nested case-control study. Non-diabetic inhabitants from a community in Chongqing were enrolled and followed up for 5 years. Clinical data were collected. Oral glucose tolerance test (OGTT) was performed at baseline and every 1-2 years. Controls were randomly selected in a 1:1 ratio to match new T2DM cases according to age, gender, and BMI. Odds ratios (OR) for T2DM were calculated by conditional logistic-regression analysis.Results:A total of 255 subjects out of the 2541 subjects developed T2DM during the 5-year follow-up. There were 141 males and 114 females in the T2DM group, aged (61.3±9.9) yrs vs. (61.4±9.8) yrs in and control group. Serum C3 was higher in T2DM group than in control group at baseline (1.29±0.23) vs. (1.25±0.21) g/L, t=-2.017, P=0.044). In T2DM group, serum C3 was positively correlated with BMI, WC, TC, TQ LDL-C, and FINS. In control group, serum C3 was positively correlated with BMI, WC, SBP, DBP, TC, TG, LDL-C, and FINS. The number of T2DM cases, levels of SBP, DBP, TC, TQ LDL-C, and FINS increased with the increasing of serum C3 level. The relationship between C3 and T2DM was much closer in population those who aged≥55 years old, at a level with BMI≥24 kg/m2, TC≥5.2 mmol/L or TG<1.70 mmol/L. After adjusting for age, gender, BMI, smoking history, family history of diabetes, physical activity, low density lipoprotein cholesterol(LDL-C) levels and systolic blood pressure (SBP), the risk of developing T2DM was still closely associated with elevated serum C3 levels (OR=1.652,95%CI 1.004～2.717, P=0.041).Conclusion:Serum C3 levels may predict the development of type 2 diabetes mellitus, especially in those who are elder or overweigh/obese, or with elevated TC or normal TG.PART 3 THE EFFECT OF SERUM LIPOPOLYSACCHARIDE BINDING PROTEIN ON PREDICTION OF TYPE 2 DIABETES MELLITUSObjective:Aims to investigate the association between serum LBP levels and the risk of developing T2DM.Methods:We performed a 5-year nested case-control study of 3,510 individuals in Environment, Inflammation and Metabolic Diseases Study (EIMDS). Clinical data were collected at baseline. Serum levels of LBP and other biochemical factors were detected later. Subjects were diagnosed as T2DM according to the results of oral glucose tolerance test (OGTT) and the World Health Organization (WHO) criteria 1998. Controls were randomly selected to match cases according to age, gender, and BMI in a 1:1 ratio. Odds ratios (OR) for T2DM were calculated by the use of conditional logistic-regression analysis.Results:During a follow-up of 5 years, a total of 255 subjects developed T2DM. There was no significant difference in serum LBP between T2DM and controls (19.78±6.40 vs.20.53±6.99, p=0.207) at baseline. All the subjects were divided into 3 groups according to the tertiles of LBP levels, with 170 cases in each group. The risk of developing T2DM was associated with LBP tertiles neither in simple model, nor after adjusting various factors.Conclusion:Under the condition of being matched for gender, age, and BMI, LBP does not improve T2DM prediction independently. |
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