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Data Mining On Diagnostic Standard Of Chronic Gastritis With Spleen-stomach Damp-heat Syndrome

Posted on:2017-05-13Degree:DoctorType:Dissertation
Country:ChinaCandidate:P ZhangFull Text:PDF
GTID:1224330488463253Subject:TCM clinical basis
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Objective Based on the modern literature, Research of Data Mining to chronic gastritis syndrome patterns, chronic gastritis with spleen-stomach damp-heat syndrome, tongue, pulse, prescriptions and drugs,drug addition and subtraction with the card. Research for the syndrome characteristics of Chronic Gastritis with Spleen-stomach Damp-heat Syndrome and syndrome by differentiation through drug effects,by syndrome differentiation through prescriptions, guiding the clinic dialectica of chronic gastritis with spleen-stomach damp-heat syndrome by CG model combined with syndromes.Clinically,through the chronic gastritis data mining of 6 cities on epidemiology(dietary preferences, and predisposing factors), general(duration, increased time) and clinical syndrome(symptoms increased time, symptoms, tongue, coated tongue, gastroscopic signs, Helicobacter pylori), and provide a quantitative diagnostic standard for chronic gastritis with spleen-stomach damp-heat syndrome.Methods Collected all the documents of "chronic gastritis" as the key words and contains "spleen-stomach damp-heat syndrome". analysed the literature of chronic gastritis(chronic atrophic gastritis,chronic superficial gastritis,chronic erosive gastritis,chronic bile reflux gastritis, epigastric fullness syndrome, Helicobacter pylori associated gastritis),about the patients from the provinces, cases, cases of males and females, syndrome types and the corresponding cases. analysed the literature of chronic gastritis with spleen-stomach damp-heat syndrome on clinical symptoms,tongue,pulse,prescriptions and drugs, drug addition and subtraction with the card, and unified the title of the above indicators. Liquorice software was used to cluster analysis, correlation analysis, the frequency, node degree, tightness of statistics. Clinical cases were collected from 6 hospitals of(Wuhan, Beijing, Xiamen, Yancheng, Hefei, Chengdu)in June 2014 to June 2015,and 600 cases of chronic gastritis patients come from the digestive clinic department. According to the chronic gastritis standard of Western medicine diagnosis and treatment, chronic gastritis with spleen-stomach damp-heat syndrome discriminate standard and clinical inclusion criteria. randomly selected cases into the spleen-stomach damp-heat syndrome group, and the rest cases were classified as non spleen-stomach damp-heat syndrome group. First the data Base was established by the software of Epi Data database, conversion into the SPSS database file, then disposed and analysed by spss20.0 software,and used multiple response analysis to explore the data between the frequency, cross correlation, used multinomial logistic regression analysis comparison between the fitting degree, K-means clustering analysis to classify comparison.Results The frequency of literature data mining to chronic gastritis with spleen-stomach deficiency was the highest, followed by liver-stomach stagnated-heat syndrome and spleen-stomach damp-heat syndrome. In the number of incident cases of liver-stomach stagnated-heat syndrome highest for 23%, spleen-stomach deficiency was 22%, spleen-stomach damp-heat syndrome was 16%, three cards were 61% in total. Chronic gastritis of spleen-stomach damp-heat syndrome’s symptoms appear frequency highest was bitter taste, the frequency of symptoms of more than 100 were bitter taste, fullness in the gastric cavith, yellow urine, epigastric pain, bad breath, nausea, epigastric burning, loss of appetite, stool pond. The frequency of main symptoms between 50~100 were epigastric pain, vomiting, thirst without desire to drink, mouth sticky, heavy cumbersome limbs. The pulse midvein was highest frequency in chronic gastritis of spleen-stomach damp-heat syndrome, 97.followed by slippery rapid pulse, moisten rapid pulse, wiry pulse, slippery pulse string, wiry rolling pulse,moisten slow pulse, rapid pulse. The highest frequency of tongue in total was red tongue, 243 times, yellow slimy coated tongue for 189 times, thick yellow coated tongue were109, greasy coated tongue were 91, the edge of the tongue tip crimson were 63 times. For the prescription of chronic gastritis of spleen-stomach damp-heat syndrome was Lan Pu Yin, ban Xia Xie Xin decoction,Wendan decoction,Sanren decoction,Huopu Xialing decoction. The highest rate of Drug use was the rhizome of Chinese goldthread, 244.The frequency above 100 of the drug were Pinellia and magnolia bark, liquorice, Poria, Radix Scutellariae, tangerine peel, dandelion. The frequency between 50~100 of the drug were the Coix seed, Atractylodes rhizome, patchouli, cardamom seed, Fructus aurantii. Symptoms of drug and node degree of maximum node were acid reflux, epigastric fullness, epigastric pain, loose stools, node degree for 22.The symptoms of the corresponding drug bamboo shavings use rate is the highest,42, followed were concha Arcae, Radix et Rhizoma Rhei, Rhizoma Atractylodis, ginger, Rhizoma Corydalis, Perrin, spin coating flower, dandelion. Various types of gastritis spleen stomach damp heat syndrome incidence rate of Guangdong, Beijing, Jiangsu, Fujian, Shandong higher than other citis, the central and western regions were relatively closed.Clinically, spleen-stomach damp-heat syndrome was the main between 2 to 5 years in the course of disease, more time 2 weeks in the increase time. The diet of Chronic gastritis with spleen-stomach damp-heat syndrome is mainly to spicy food, accounting for 74.4%, followed by greasy food, preserved food, 73.4% and 64.5% respectively.Drinking,postprandial symptoms significantly increased, accounting for 68.2% and 64.2% respectively.Afternoon symptoms more obvious, accounting for 61.7% of the cases. The frequencys of chronic gastritis with spleen-stomach damp-heat syndrome, abdominal distension accounted for 75.9%, heavy cumbersome limbs 65%, bitter taste 58.1%.The tongue color of Chronic gastritis with spleen-stomach damp-heat syndrome was accounted for62.6% in red tongue, red tip of tongue was 49.8%; the spotted tongue of tongue shape was 73.4%, swollen tongue was 37.4%, tough tongue was 30.0%. Red tongue, red tip of tongue, spotted tongue was statistically significant(P<0.05) by Chi-Square test.Yellow fur was accounting for 64.5%, moss white 26.1%; In the tongue coating distribution region, root of tongue was 86.2%, red tongue was 62.6%. A number of multivariate logistic regression analysis to estimate the parameters of tongue coating were P<0.05 with yellow fur and greasy fur.The Syndrome of Heat Than Damper in Chronic gastritis with spleen-stomach damp-heat syndrome group,greater than 50% was spotted tongue,73.4%, Yellow fur 63.5%, red tongue 62.6%, bitter taste 58.1%, dry mouth to drink less 54.2%. The Syndrome of Damper than heat in chronic gastritis with spleen-stomach damp-heat syndrome group,more than 50% mainly have greasy 78.3%, prick tongue 73.4%, yellow tongue fur 63.5%, body trapped heavy 65.0%, loose stools 51.2%.Cases of chronic gastritis with spleen-stomach damp-heat syndrome group in Equal heat and humidity more than 50% were thick libngual fur 79.8%, greasy tongue coating 78.3%, spotted tongue was 73.4%, yellow tongue 63.0%, bitter taste 58.1%. Symptoms of the heavy sensation in the limbs and body, bitter taste, thirst to drink less, peculiar smell sensation, loose stools was significant difference(P < 0.01) between the heat syndrome and damp heat syndrome group.Thirsty to drink less was 54.2%, peculiar smell sensation is 52.7%, loose stools 51.2%. In the hronic gastritis with spleen-stomach damp-heat syndrome group, chronic superficial gastritis was 86.2%, with chronic erosive gastritis 71.9%, gastric mucosa red alternating with white, and red mainly 86.2%. In various types spleen-stomach damp-heat syndrome of chronic gastritis were bitter taste, fullnessor distension, yellow urine, pain in the stomach, halitosis, nausea, epigastric burning sensation, poor appetite, loose stools.The Mainly pulses had wiry rapid pulse, rapid pulse, soft pulse; The Mainly tongues had red tongue,tip and side red tongue, yellow greasy or yellow thick or greasy.Conclusion Literature research in chronic gastritis syndrome was liver-stomach stagnated-heat syndrome>spleen-stomach deficiency>spleen-stomach damp-heat syndrome in turn.the above syndrome type of chronic gastritis accounted for 70% in total. Chronic gastritis with spleen-stomach damp-heat syndrome from high to low in order was mouth pain, fullness in the stomach full, yellow urine, epigastric pain, bad breath, nausea, epigastric burning sensation, poor appetite, loose stools, epigastric pain, vomiting, thirst without desire to drink, sticky and greasy mouth, heavy sensation in the limbs and body. The pulse from high to low was slippery rapid pulse, moisten rapid pulse, wiry pulse, slippery pulse string, wiry rolling pulse,moisten slow pulse, rapid pulse. red tongue, yellow slimy coated tongue,thick yellow coated tongue,greasy coated tongue,the edge of the tongue tip crimson. For the prescription of chronic gastritis of spleen-stomach damp-heat syndrome was Lan Pu Yin, ban Xia Xie Xin decoction,Wendan decoction,Sanren decoction,Huopu Xialing decoction. The highest rate of Drug use were the rhizome of Chinese goldthread, Pinellia and magnolia bark, liquorice, Poria, Radix Scutellariae, tangerine peel, dandelion. Coix seed, Atractylodes rhizome, patchouli, cardamom seed, Fructus aurantii. Symptoms of drug and node degree of maximum node were acid reflux, epigastric fullness, epigastric pain, loose stools, node degree.The symptoms of the corresponding drug bamboo shavings,concha Arcae, Radix et Rhizoma Rhei, Rhizoma Atractylodis, ginger, Rhizoma Corydalis, Perrin, spin coating flower, dandelion. Various types of gastritis spleen stomach damp heat syndrome incidence rate of Guangdong, Beijing, Jiangsu, Fujian, Shandong higher than other citis.Clinically, spleen-stomach damp-heat syndrome was the main between 2 to 5 years in the course of disease, more time 2 weeks in the increase time. The diet of Chronic gastritis with spleen-stomach damp-heat syndrome is mainly to spicy food,, followed by greasy food, preserved food.Afternoon symptoms more obvious. The main syndromes of chronic gastritis Including: symptoms, tongue three parts. In the main symptoms of chronic gastritis with spleen-stomach damp-heat syndrome, chronic gastritis frequency from high to low were abdominal distension full > epigastric pain > belching > heartburn sense > eat less Nadai > loose stool > limb trapped weight > mouth > sleep difference > hiccup > constipation > reflux > smell sense > thirsty to drink less stomach > in noisy > evil heart want to spit > chest tightness > yellow urine. Finally selected percentage is more than 50% and has significant entries as chronic gastritis of spleen stomach damp heat syndrome of table of contents, determine: 1. Abdominal distension, limb trapped weight, the bitter taste of mouth, thirst to drink less, the sense of smell, the loose stool, seventhly, belching, the sleep difference with eight symptoms related factors of chronic gastritis of spleen-stomach damp-heat syndrome.Comprehensive literature and clinical research, formulated the following chronic gastritis spleen stomach damp heat syndrome of quantitative diagnosis of content, including specific symptoms of chronic gastritis, chronic gastritis clinical symptom severity grading, spleen and stomach damp heat syndrome syndrome severity quantification. The main syndromes is determined as follows: 1 epigastric fullness or epigastric pain or epigastric burning pain or epigastric pain(specific symptoms), II heaviness in the body, bitter taste in the mouth, thirst to drink less, the halitosis, the loose stool. Seventhly, anorexia, the tongue tip side of the red with prick, tongue body fat, or on the margins of the tongue tip red with prick tongue old; anlyses the base of the tongue with yellowish fur thick, or the base of the tongue yellow greasy moss, thick and greasy or the base of the tongue with yellowish fur, tongue or in the rear of the yellow thick moss, or in the middle of the tongue, root moss yellow greasy, tongue or rear moss yellow thick and greasy the pulse are slippery, slippery, moisten the number. With the 8 9 10, which is a specific symptom of chronic gastritis and tongue and pulse diagnosis of chronic gastritis.To grade the clinical symptoms of chronic gastritis(refer to table 2-1). spleen-stomach damp-heat syndrome and the degree of quantization: tongue as the severity of the quantization: mild for margin and tip of the tongue red with little prick, base of the tongue yellow greasy moss. Moderate margin and tip of the tongue red with prick, thick and greasy tongue with yellowish fur, tongue or in the rear of the thin yellow greasy coating, or edge of the tongue tip red tongue body fat, tongue fur thick and greasy. Severe for the edge of the tongue tip crimson with obvious prick, tongue old, tongue in the rear of the moss yellow thick greasy; or the edge of the tongue tip crimson with obvious prick, tongue old, thick and greasy tongue coating dryness; tip or tongue side of red, fat tongue, tongue fur in the rear part of the thick and greasy; or margin and tip of the tongue is dark red, tongue body fat, tongue moss in the rear part of the thick and greasy.
Keywords/Search Tags:chronic gastritis, spleen-stomach damp-heat syndrome, quantitative diagnostic standard, data mining
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