Clinical Research On Pulverization Inhalation Therapy Of Garlic Allicin Injection For The Secondary Epiphyte Infection Affection Of Agedness’ Deep Respiratory Tract And The Influence On Different Syndrome Of Chinese Medicine

Taken the Chinese medicine theory as the instruction and based on the preliminaryexperimental study and former clinical practice, the thesis conducts the clinicalresearch on pulverization inhalation therapy of garlic allicin injection for the secondaryepiphyte infection affection of agedness’ deep respiratory tract and the influence ondifferent syndrome in a traditional herbalist doctor view, scientifically discusses theeffective curative for the secondary epiphyte infection affection of agedness’ deeprespiratory tract so as to enhance the treatment function.Aim: to observe the clinical curative effect of pulverization inhalation therapy of garlicallicin for the secondary epiphyte infection affection of agedness’ deep respiratory tract,to conduct index statistics analysis of epiphyte elimination effect, the clinical curativeeffect, inflammation factor and body fluid immunity, and to provide the scientific basisfor opening the out the function mechanism of pulverization inhalation therapy ofgarlic allicin;Method: According to the research, the selected and effective patients are 38 persons.They are divided into two groups stochastically by random numeric table, 16 examplesfor comparison group (western medicine comparison group) and 22 examples fortreatment group (pulverization inhalation therapy of garlic allicin injection group).Each patient of comparison group takes 50mg Fluconazole twice a day, and eachpatient of treatment group inbreathe 7.5mg pulverization of garlic allicin injection plus20ml physiological brine twice a day. Seven days form a treatment period and the totalis two periods.Security index observation: A check-up record will be taken before and after takingdrugs respectively concerning body temperature, the breath, the pulse, the bloodpressure, general blood items, the urine, the bowel movement items, the liver, thekidney function as well as the electrocardiogram (ECG). Curative effect index observation: phlegm epiphyte cultivation (three times phlegmepiphyte cultivation both before and after taking drugs and observation); Inflammationfactor (C-Reactive Protein, CRP, Human Interleukin-6(IL-6), Human Interleukin-8(IL-8)); body fluid immunity index (IgA, IgG, IgM, C3, Ca); integral of clinicsyndrome in Chinese medicine view (integral register of main symptom and minorsymptom);Traditional Chinese medical appearance observation: to record all the syndrome ofpatients and classify the type;Result: Total effective rate of pulverization inhalation therapy of garlic allicininjection for the secondary epiphyte infection affection of agedness’ deep respiratorytract is 86.36%, while the total effective rate of comparison group is 37.5%. Thedifferences have statistical significance (P〈0.05). The epiphyte elimination effect isobvious and the rate of elimination achieves 59.09%. The differences with comparisongroup have no statistical significance (P〉0.05). The differences of inflammation factorCPR and IL-8 have no statistical significance before and after treatment (P〉0.05), butIL-6 decreases greatly after treatment and the differences before and after treatment areobvious (P〈0.05) with similar change degree of comparison group (P〉0.05). Thedifferences of treatment group’s immunity index have no statistical significance (P〉0.05). The clinic effects on three different syndrome of treatment group aredifferent. The total effective rate and the epiphyte elimination rate are 100% and 100%respectively for syndrome of turbid phlegm obstructing lung. The total effective rateand the epiphyte elimination rate are 71.42% and 28.57% respectively for syndrome ofphlegm-heat obstructing lung. The total effective rate and the epiphyte elimination rateare 87.50% and 50% respectively for syndrome of deficiency of both qi and yin oflung. In spite of epiphyte elimination effect of clinic symptom curative effect, there arestatistical significance for the differences between syndrome of turbid phlegmobstructing lung and other syndromes (P〈0.05). While the difference between othertwo syndromes, syndrome of phlegm-heat obstructing lung and syndrome ofdeficiency of both qi and yin of lung, have no statistical significance ( P〉0.05 ).Conclusion: The patients of secondary epiphyte infection affection of agedness’ deeprespiratory tract are aged and weak. Their immunity function level is low. Sometimes because of long-term and big dosage use of broad-spectrum antibiotics andimmunosuppressant drug after suffering from basic illness, they have root deficiencybut excess manifestation, deficincy combined with excess, or syndrome of phlegm dueto deficient vital qi, this is the key factor of illness. Therefore, strengthening andconsolidating body resistance and benefiting qi for activating blood circulation so as toenhance immunity function is the important principle for treatment. Garlic allicin hassolid curative effect on improving the clinic symptom and epiphyte elimination ofsecondary epiphyte infection affection of agedness’ deep respiratory tract sufferers,especially to the patients of syndrome of turbid phlegm obstructing lung. The curativemechanism of garlic allicin may be by reducing the level of IL-6 to prevent the specialtendency attraction of PMN, to hold back the assembly tendency of inflammationfactor, to decrease the detention time of PMN in capillary vessel of deep respiratorytract, and to reduce the damage to endothelial cell of capillary vessel of deeprespiratory tract, so as to enhance the immunity recovery ability of the body, strengthenvital qi to eliminate pathogenic factor and treat both manifestation and root cause ofdisease. So pulverization inhalation therapy of garlic allicin injection is safe, reliableand has no toxic or side effect and can be used for treatment of for the secondaryepiphyte infection affection of agedness’ deep respiratory tract.