Studies Of The Method Of Dispersing The Depressed Liver-energy, Invigorating The Spleen And Both Applying Cold And Heat TCM On Treating Irritable Bowel Syndrome

IRRITABLE BOWEL SYNDROME(IBS) IS A DISEASE WHICH EXHIBITSINTESTINAL DYSFUNCTION. GOING WITH THE ECONOMICAL DEVELOPEDAND MEDICINE IMPROVED, THE INCIDENCE GRADUALLY RISES. IT HASBEEN BECOME THE MOST COMMON FUNCTIONAL DISORDER. ’ZHU SHAODI JIANG DECOCTION’ (ZSDJD) IS AN EFFECTIVE PREPARATION FROM PURECHINESE HERBS IN TREATING IBS. ON THE BASIS OF FORMER RESEARCH,THIS PAPER WAS SYSTEMICALLY STUDIED FROM THE THREE ASPECTS:EXPERIMENT, CLINIC AND THEORY.IN EXPERIMENTAL RESEARCH, ADOPTING THE GASTROINTESTINALDYSMOTILITIED MODEL MICE CAUSED BY THE DECOCTION OF RADIX ETRHIZOMARBE (INCLUDING DIARRHEA MODEL), TESTED IT BY DYING THECOLON WITH CARBON IN RATS, THEN KILLED THE RATS AND TOOK THECOLON, MAKING MUSCLE STRIPS. THE EFFECTS OF CHANGYANDECOCTION ON THE ACTIVITY OF THE STRIPS WERE OBSERVEDRESPECTIVELY AND TOOK THE MOSAPRIDE FOR CONTRASTING.RESULTS: THERE IS NO SIGNIFICANT DIFFERENCE BETWEEN ZHU SHAODI JIANG DECOCTION AND MOSAPRIDE IN PROMOTING COLONIC CREEPINGOF SLOW TRANSIT CONSTIPATION (STC) MODEL RATS. ZHU SHAO DI JIANGDECOCTION CAN ALSO REDUCE THE COLONIC CREEPING FREQUENCY OF THE GASTROINTESTINAL DYSMOTILITIED MODEL RATS.CONCLUSION: ZHU SHAO DI JIANG DECOCTION CAN ADJUST THEMOTILITY OF THE ISOLATED COLONIC MUSCLE STRIP IN THEGASTROINTESTINAL. DYSMOTILITIED MODEL RATS AND IT IS THETWO-WAYS REGULATED EFFECTS.IN CLINICAL RESEARCH, 100 INVOLVED IBS (DIARRHEA TYPE) PATIENTSWERE RANDOMLY DIVIDED INTO THE TREATMENT GROUP(60 CASES,TREATED BY ZSDJD) AND THE CONTROL GROUP(40 CASES, TREATED BYBU-PI YI-CHANG PILL),AND WERE TREATED FROM THREE TO SIX WEEKS.AS A RESULT, CLINICAL SYMPTOMS SUCH AS ABDOMINAL PAIN,DIARRHEA, ABDOMINAL DISTENTION AND ET AL IN THE TREATMENTGROUP COULD BE IMPROVED. IT’S TOTAL EFFECTIVE RATE WAS 91.6％,AND THAT IN THE CONTROL GROUP WAS 67.5％. THE FORMER WAS MUCHBETTER THAN THE LATTER (x~2=7.930,P＜0.01).