Comparative Study Of Photodynamic Cancer Radiotherapy And Post-installation

OBJECTIVE:The purpose of this study was to assess the feasibility and effectiveness of5-ALA PDT and to compare the outcomes of afterloading radiotherapy and5-ALA PDT in tumor bearing mice with human cervical cancer.METHODS:28Balb/c nude mice models of human cervical cancer were equally divided into4groups: afterloading group, PDT1time group, PDT6times group, and tumor control group, while setting a healthy control group(n=7) as well.600cGy X6times of afterloading radiotherapy were given to the mice in afterloading group. In PDT groups, we irradiant the tumor with635nm laser4hours after1.2mg5-ALA was delivered locally. After6weeks of treating and observation, compare the effects and side effects on mice in each group.RESULTS:No significance has been shown in mean live time of all5groups. Tumor volumes of mice in PDT6times group and afterloading group are significantly smaller than mice in tumor control group(p=0.000both) at the end of study. Difference of the tumor volumes between PDT6times group and afterloading group was not significant(p=0.084). The side effect to skin near the tumor is more serious in afterloading group than in PDT groups.CONCLUSIONS:5-ALA photodynamic therapy seems to get similar effects as, but cause less side effects than afterloading radiotherapy on treating uteri cervix cancer, and the outcomes will get better when treating for several times. When administrated locally,5-ALA PDT hardly affects the functions of ovaries.