Prognostic Value Of Growth Differentiation Factor-15in Patients With Coronary Atherosclerotic Heart Disease

BackgroundGrowth differentiation factor15(GDF-15) is a member of the transforming growth factor-β cytokine superfamily. It is induced in the cardiovascular cells by many risk factors of coronary artery disease. Circulating levels of GDF-15may relate to these risk factors and provide prognostic information in patients with coronary atherosclerotic heart disease.Methods and ResultBlood samples were obtained after CAG from158patients without acute myocyte infarction. GDF-15levels were determined by enzyme linked immuno-sorbent assay. Clinical and biochemical informations were recorded and all patientes were followed up. Circulating levels of GDF-15positively related to age, diabetes and Gensini score of the coronary artery. Patients with higher level of GDF-15had a worse prognose during following-up. A significant interaction existed between GDF-15level on admission and the effect of treatment strategy on the primary composite end point.ConclusionsGDF-15is a potential tool for risk stratification and therapeutic decision making in patients with coronary atherosclerotic heart disease. A prospective randomized trial is needed to validate these findings.