Study On Luminescence Properties And Applications Of Metal Functional Complexes And Sulfide Quantum Dots

Functional material chemistry plays an important role in biomedical applications that are closely related to human health.Among these materials,lanthanide complexes,ruthenium complexes and sulfide quantum dots have important applications in fluorescence imaging,immunoassay,nuclear magnetic imaging,catalysis and photodynamic therapy due to their special optical properties.Therefore,in this paper,we focused on the biological applications of new functional materials and prepared new metal functional complex materials and transition metal dichalcogenides quantum dots,in order to explore their applications in sensing and photodynamic therapy based on their fluorescence properties,providing important experimental and theoretical reference sense for the design and synthesis of multifunctional materials with excellent performance.This paper will be divided into five chapters:1.This section introduced the research background of lanthanide complexes,ruthenium complexes and transition metal dichalcogenides quantum dots in the applications of biomedicine briefly.And then,the research progress on the recognition of lanthanide complexes,photodynamic therapy of ruthenium complexes and metal ions detection of MoS₂ quantum dots were mainly reviewed.2.A functional amide-type pincer ligand L1 was designed and synthesized,which could effectively capture terbium ions to form a phosphorescence complex-based chemosensor Tb-1.The chemosensor could further coordinate with lead ions under weak basic condition and formed Pb²⁺-induced hydroxide nanoclusters,which display a turn-on phosphorescence response.An understanding of the recognition mechanism of the terbium complex-based chemosensor and the application of the characteristic spectra of lanthanide ions might be able to provide more opportunities to develop highly selective optical chemosensors.3.A novel ligand L3 based on 1,4,7,10-tetraazacyclododecane-1,4,7-tris（acetic acid）derivative and its was terbium complex Tb-3 were designed and synthesized,and the response to zinc ions in aqueous solution of Tb-3 was tested.The results showed that the complex exhibits a ratio detection of zinc ions with a specific selectivity,which is not interfered by other metal ions including cadmium ions.In addition,the probe was successfully applied to the fluorescence imaging of living cells,which showed the probe has good membrane permeability,and it could detect the zinc ions in living cells.The probe demonstrated potential value in study the role of zinc ions in biological systems.4.A novel ligand L4 based on phenanthroline derivative and its functional ruthenium complexes Ru-4 were designed and synthesized.We investigated the phosphorescence properties and photodynamic properties of Ru-4 in methanol.In addition,the complex Ru-4 was successfully applied in live cells imaging and we researched the cytotoxicity of Ru-4 before and after irradiation in cells.The experiments demonstrated that the complex Ru-4 is a good photosensitizer in PDT and has potential applications in cancer treatment.5.According to the characteristics of nanosheet growth in the process of solid phase synthesis of MoS₂ nanosheets,we proposed a simple and efficient method for mass production of MoS₂quantum dots（MSQDs）by a sequential combination of template-assisted solid-phase synthesis and sonication-assisted solvent exfoliation route.With such a strategy,uniform MSQDs with average size of 3.4 nm were produced with a high yield of 25 wt%,and displayed sufficient water solubility and remarkable fluorescence properties.The MSQDs have been utilized as a probe for selective and sensitive detection of Fe³⁺ions,and exhibited high fluorescence stability under a wide range of pH and continuous irradiation.Furthermore,the MSQDs could be used for the fluorescence imaging of Fe³⁺in living cells,which exhibited practical potential for various bio-applications.Finally,we fabricated water-soluble WS₂ quantum dots through this method and the WS₂ quantum dots were utilized as a probe for selective and sensitive detection of Fe³⁺ions.