The Treatment Of Male Infertility By Traditional Chinese Medicine Cilnical Experience And Academical Thought Of Wang Guanghui

Objective:Researched the clinical experience and academic thought of the old doctor of traditional Chinese medicine(TCM) named Wang Guanghui in the treatment of male infertility, and conducted randomized controlled clinical trials(RCT) to test the safety and effectiveness, in order to exploring effective agent and treatment of TCM for the treatment of male infertility, and forming a complete theoretical system of TCM and diagnosis and treatmentplanBesidesconducted randomized controlled clinical trials(RCT)to test the safety and effectiveness.Methods:First of all, extensived literature data, and understood the treatment actuality and progress of male infertility between Chinese and western medicine diagnosis, familiared with various schools of thought and the historical origin of traditional Chinese medicine.With the way of learning, clinical experience, and the scene view questions, summary the clinical cases of Wang Guanghui, to understand his clinical features in the treatment of male infertility, explore the unique dialectical thinking and prescribing habits in the treatment of male infertility, and form a unique set of diagnosis and treatment.The clinical study used male heat capsule to treating of male infertility caus-ed by se men liquefaction. The subjects are randomly divided into the treatmentgroup and control groupandbothofthetwo groups inclue 100 cases.The treatment course will be 3 months. O bserve the liquefaction timedensity vitalitydeformity rate of spermand the change of TCM syndrome integrationand the patients’change of the Blood RT, Urine RTStool RT,function of Live-r and Kidney and electrocardiogram (ECG),processed statistical analysisand Comp ared the clinical curative effect and TCM syndrome curative effect of t-wo groups. Anima 1 experiments mainly completed the acute toxicology test, to testing male measured heat ca psule on mice of the median lethal dose and maxi-mum to lerance, and completed safety assessment.Results:Literature review found that, based on Doctors in past dynasties’views, there are extremely close relations between male infertility with and the function of the state and five zang-and the rise and fall of Qi and blood, especially the liver and spleen and kidney. Wang Guanghui thinks that there is a close relationship between reproductive function and the ups and downs of body Jing-Blood. In the dialectical process, he attaches great importance to heat, dampness, blood stasis and toxin Fuzheng coexist, make do without injury. He believes that reproductive function and human "blood" and have a close relationship. The spleen kidney two dirty were congenital and acquired, blood is derived, is closely related with the occurrence of male infertility. Renal refine the raw kidney, kidney essence deficit deficiency combined with various factors lead to consumption injury kidney and male infertility patients often present with kidney Qi deficiency syndrome. The modern daily life dysfunction impaired the function of spleen and stomach. Part of the male infertility patients performance for spleen deficiency and even when the spleen wet Sheng syndrome. Seminal fluid is not liquefied in the main aspects of wet, heat, blood stasis and three kinds of pathogenic factors. This disease is mainly associated with Yin deficiency and Qi deficiency. Male infertility often shows syndromes of chronic illness into stasis, chronic illness into the network, so the treatment should pay attention to and strengthen both Quyu Tongluo. He concluded many years of clinical experience, combined with the change of modern life style and modern medical research progress and generalize the most common male infertility clinical syndromes for these 4 types:kidney Qi deficiency, spleen deficiency deficiency, damp heat and blood stasis, blood stasis syndrome. He believes that each syndrome type does not exist in isolation, often reciprocal causation, interaction, performance for the virtual subject, mixing truth with falsehood, chronic illness into the pathological changes of blood stasis. On this basis, he puts forward the basic pathogenesis of male infertility is insufficiency of the kidney deficiency, yin and Yang Qi and blood disorders for this, damp heat, blood stasis as the standard. On the clinical characteristics and syndrome differentiation of the disease, he developed male Shengjing Capsule(Lu medicine word Z09080156), Qiangsheng Yiti Capsule(Lu medicine word Z09080190), male Qingre Capsule(Lu medicine word Z09080189), Qizhi Capsule(Lu medicine word Z09080191), are used to treating patients with different types, puted into clinical use, achieved remarkable clinical curative effect. His points about semen liquefaction from wet from the concept of heat from the blood stasis treatment is also well to guiding the clinical treatment of semen liquefaction. The linical research shows that, the total effectiveness of clear heat treated with male semen liquefaction is 91.9%, and the total effectiveness of TCM syndrome integration is 92.9%, obviously higher than that of control group(p<0.05). He also found clear heat capsule can significantly improve sperm concentration and energy. and prompt semen liquefaction. and there is significant difference compared with the control group(p<0.05). Two groups of safety index are good. Animal experiments showed that the male heat capsule did not appear any acute toxicity, and the maximum tolerated dose equivalent to 302.7 times the daily clinical dosage, suggesting that the drug is safe for clinical use.Conclusion:Wang Guanghui’s academic thoughts on the treatment of male infertility includes:sperm production, development, excretion, as well as the vitality of the sperm, semen liquefaction time. They are all closely related to the function of the kidney. Semen liquefaction is closely related to three kinds of pathogenic factors, wet, heat and blood stasis. Male infertility longer course of disease, often performance for the long illness into stasis, long illness into complex phenomenon, this phenomenon and found in all syndromes. Male Shengjing capsule and physical benefits capsule, male Qingre capsules, Qizhi capsule is respectively for treatment of kidney qi deficiency, spleen deficiency is the representative formula of deficiency, damp heat and blood stasis, blood stasis type of male infertility. Clinical research confirmed that the male sterility caused by non liquefaction of semen is safe and effective, and has no toxic and side effect.