Relationship Between Common TCM Constitution Types And Polymorphism Estrogen Receptor α Gene Study In Postmenopausal Knee Osteoarthritis

Objective: We acquire TCM constitutional types,characteristics and influencing factors of postmenopausal knee postmenopausal patients by questionnaire survey.Estrogen receptor α polymorphism were studied in Qi deficiency KOA patients.We discuss the effect for KOA on the occurrence,development and transformation of the KOA by TCM constitution and estrogen receptor α gene polymorphism.Treat the Qi deficiency of KOA patients by Self-made Yi Qi Chu Bi Tang and observe the clinical effect and its relationship with estrogen receptor α gene polymorphism.Provide practical and theoretical support for the Exploration of personalized medicine.Methods: Choosing 736 postmenopausal KOA patients(aged 48—70)were treated in Luoyang zheng gu Hospital Henan Province from January 2014 to October 2016.All subjects were post-menopausal women and menopause duration more than one year.Collect KOA cases in strict accordance with the subject inclusion and exclusion criteria selection;and let them fill out the questionnaire.All cases were selected for investigation and analysis of TCM Constitution.Treat the Qi deficiency by Self-made Yi Qi Chu Bi Tang;At the same time analysis the gene polymorphism of estrogen receptorα.Result: Distribution of nine common constitution in the postmenopausal women ranged before three is Qi deficiency(47.01%),Yang deficiency(23.23%),Phlegm-dampness(18.21%).As can be seen from the table,most KOA patients are biased constitution(94.84%).ERαs2234693 polymorphic nomal appear in all of Qi deficiency,yang deficiency and phlegm-dampness constitution patients.when treat the patients by Self-made Yi Qi Chu Bi Tang.The patients with Erα-s2234693 of CC/TC genotype curative efficiency up to 93.90 percent,but to the TT genotype curative efficiency is just 75.45 percent.Therefore,Self-made Yi Qi Chu Bi Tang for CC/TC genotype group curative effect is better than TT genotype.