Therapeutic Evaluation Of The Treatment Of Moderate To Severe Persistent Allergic Rhinitis With Spleen Deficiency By Separating Moxibustion Combined With Reynolds

Objective:To explore the effect of medicinal moxibustion combined with Rhinocort Nasal Spray treatment on moderate to severe persistent allergic rhinitis with spleen deficiency.Methods:1.Group:A total of 63 patients who suffering at moderate to severe persistent allergic rhinitis with spleen deficiency were randomized by random number table into receiving medicinal moxibustion combined with Rhinocort treatment as observation group(31 cases)or Rhinocort treatment as control group(32 cases).During the process of research,1 case of observation group was suspension and 2 cases of control group were shedding.Finally,60 patients were included in the statistics.2.Treatment:The recommended dosage for patients in two groups is 4 dose(256μg)per day administered as one spray per nostril of Rhinocort Nasal Spray 64μg once each in the morning and evening.Continuous use for 4 weeks,if the maximum benefit has been achieved and symptoms have been controlled,reducing the dosage in maintaining control of the allergic rhinitis symptoms or use original dose for the next 4 weeks.The observation group combined with medicinal moxibustion treatment.Medicinal moxibustion treatment:(1)Herbal cake and moxa cone preparation:Prescription:Astragalus mongholicus 5ana,Bighead atractylodes rhizome 5ana,Rhizoma atractylodis 5ana,Rhizoma zingiberis 5ana,Cinnamon lana,Borneol lana.Preparation:Grinded all the above herbs into powder,then reconciled with ginger juice.Made it into herb cakes which specification were 2 to 3cm in diameter and 0.8cm in thickness,then punched holes in the middle of them.Molded the fine moxa into cones which specification were 2cm in bottom diameter,2.5cm high and weighs about 2.5g.(2)Point selection:GV29,LI4,ST36,CV8.(3)Moxibustion:GV29 can be moxibusted for 4 cones in 20mins,LI4&ST36 can be moxibusted for 8 cones in 40mins,CV8 can be moxibusted for 10 cones in 50mins.(4)Treatment:It was be done every other day(3 times per week)for a succession of 8 weeks.3 Follow-up Visit:The treatment succession was 8 weeks in both groups.There were 12 weeks Follow-up visit in observation group and 8 weeks in control group.4 Index:The primary evaluation index VAS and the secondary evaluation index TCM Syndrome Scale,RQLQ were assessed before treatment,and then every 4 weeks during treatment period and follow-up period.Results:1 Treatment period:(1)After 4th,8th week of treatment,the VAS,TCM Syndrome Scale,RQLQ were significantly improved in observation group(P<0.05).After 8th week,all nasal symptom scores were significantly decreased compared with after 4th week(P<0.05)except Nasal itching in VAS(P>0.05).The overall effective rate were 83.3%after 4th week and 86.7%after 8th week,while compared with each other there was no statistical significance(P>0.05).(2)After 4th,8th week of treatment,the VAS,TCM Syndrome Scale,RQLQ were significantly improved in control group(P<0.05).After 8th week,all nasal symptom scores were significantly decreased compared with after 4th week(P<0.05)except Sleep in RQLQ(P>0.05).The overall effective rate were 76.7%after 4th week and 83.3%after 8th week,while compared with each other there was no statistical significance(P>0.05).After treatment,the the quality of life improved in both groups,while 8 weeks treatment may be better than 4 weeks.(3)Between two group comparison,there was no statistical significance in the VAS,TCM Syndrome Scale and RQLQ(P>0.05)after 4th,8th week treatment.But compared with the dosage in 5th to 8th week for maintaining control of the allergic rhinitis symptoms,combination therapy group was significantly less than Rhinocort group(P<0.01).2 Follow-up visit:(1)Compared with after 8 weeks treatment,VAS,TCM Syndrome Scale,RQLQ score in observation group in the 4th week of follow-up visit period were significant higher(P<0.01),while still lower than baseline(P<0.01).In the later follow-up,the nasal symptoms and signs of the patients were stable.The overall effective rate were 80.0%in 4th week,76.7%in 8th week,73.3%in 12th week after 8 weeks treatment,while compared with each other during the follow-up or after 8th week treatment,there were no statistical significance(P>0.05).(2)Compared with after 8 weeks treatment,VAS,RQLQ score in observation group in the 4th week of follow-up visit period were significant higher(P<0.01),while still lower than baseline(P<0.01).TCM Syndrome Scale has no significant changed during the follow-up(P>0.05).The overall effective rate was 56.7%in 4th week of follow-up,while compared with after 8th week treatment there was significantly lower(P<0.05).It cannot be an effective statistics in the 8th week of follow-up,because of half of the patients in the control group required treatment during the 5th to 6th week of follow-up.(3)Compared two groups,there was an statistical significance(P<0.05)showed in both VAS and RQLQ scores in 4th week of follow-up,while there was no statistical significance in TCM Syndrome Scale(P>0.05).Conclusion1 Medicinal moxibustion combined with Rhinocort Nasal Spray treatment can significantly improve moderate to severe persistent allergic rhinitis with spleen deficiency,2 The dosage used in maintaining control of the allergic rhinitis symptoms in combination therapy group was less than Rhinocort group.3 The therapeutic effect can last for at least 12 weeks after 8 weeks medicinal moxibustion combined with Rhinocort Nasal Spray treatment.