Serum Of 25-hydroxyvitamin D And Intact Parathyroid Hormone Levels In Postmenopausal Women With Hip And Upper Limb Fractures

Objectives: To assess the serum levels of 25-hydroxyvitamin D(25[OH] D)and intact parathyroid hormone(i PTH)levels in postmenopausal women with hip and upper-limb fractures from North China.Method : Sera were drawn in 2011–2013 from 335 postmenopausal women who were diagnosed as hip fracture and 335 matched controls that did not experience a fracture in the Affiliated Hospital of Qingdao University.The fasting venous samples were analyzed for25[OH]D,i PTH,alkaline phosphatase(ALP),calcium and phosphorus.All women answered a standardized questionnaire designed to document putative risk factors of fractures.Results:Serum 25[OH] D levels were significantly(P<0.0001)lower in patients with hip fracture as compared to normal cases.Multivariate logistic regression analysis adjusted for common risk factors showed that serum 25[OH] D≤20ng/m L was an independent indictor of hip fracture(OR =2.979;95% CI: 2.111–4.204)and hip-fracture sustain concomitant upper-limb fractures(OR =4.765;95% CI: 1.596-10.124).The area under the receiver operating characteristic curve of 25[OH] D was 0.77(95% CI,0.68–0.84)for hip-fracture and 0.80(95% CI,0.72–0.89)for hip and upper-limb fractures.Conclusion: Vitamin D insufficiency and secondary hyperparathyroidism were common problem in postmenopausal women who had suffered a hip and upper-limb fracture,our study showed that serum 25[OH] D at admission was significantly reduced in postmenopausal women with hip and upper-limb fracture,suggesting that these alterations might participate in the pathophysiology of fracture in postmenopausal women.Serum25[OH] D levels could be seen as one powerful biological marker of risk of concomitant hip and upper limb fractures.