Synthesis And Properties Of Metal-organic Frameworks Based On Curcumin

Metal-Organic Frameworks(MOFs)are a class of porous materials formed by metal centers and organic ligands with coordination bond linkages.MOFs possess diverse structures,controlled pore sizes and high surface area,therefore they have attracted extensive attention in the past decades for various applications.Among the wide applications,the one for biomedicine and biological raises some specific requirements such as biological activity,biocompatibility,biosafety of degradation products and particle size controbility.This thesis focuses on the design and synthesis of medicine metal organic frameworks(medi-MOF)and intensively studies on the morphology and porous structures of MOFs based on curcumin,which is an active drug molecule.In addition,the potential applications of such materials in biological and chemical fields are explored.The main results are outlined as follows:1.A nitrogen-containing curcumin derivative with antibacterial and anti-inflammatory activity was synthesized.The biocompatible zinc ions and the curcumin derivative were used to construct two new medicine MOFs,named medi-MOF-2 and medi-MOF-3.Both MOFs were comprehensively characterized and the crystalline structure of medi-MOF-2 was solved through single crystal diffraction.The drug loading performance for medi-MOF-2 was carefully tested.The ibuprofen was selected as a model drug being loaded and released,and the drug loading capacity was 196.3 mg/g for medi-MOF-2.It is found that the two drug molecules ibuprofen and curcumin can be released together to achieve the goal of drug synergy.2.Nanosized medi-MOF-1 crystals were prepared by microwave-assisted coordination modulation method.Three kinds of molecules with the same coordinating groups to curcumin play the role of modulators.Their competion with the coordination of curcumin blocks the further growth and extension of the crystals.The minimum size of medi-MOF-1 nanocrystals reached to about 100 nm under microwave heating.The crystal size and morphology can be adjusted by changing the concentration of the modulators.At last,the growth mechanism of nanosized medi-MOF-1 was discussed.3.Hierarchical medi-MOF-1 was synthesized with a templating method.Triblock copolymer F127 was used as the template to participate in the medi-MOF-1 synthesis process,resulting in hierarchical pores at both micro-and mesopores scales.The sizes of mesopores were regulated from 3 nm to 10 nm by varying the amount of template.A protein with great significance in the redox reaction of plants and animals,namely Cyt c was selected as target compound to load into the mesopores of H-medi-MOF-1.The maximum loading was up to 160 mg/g.The enzyme activity of Cyt c@H-mMOF-1 composites was tested,and the results showed that the enzyme molecules loaded in the H-medi-MOF-1 exhibited good enzyme activity.Successful loading of enzyme in H-medi-MOF-1 can improve its catalytic efficiency and simutanously retain the recovery and recyclablity of the enzyme.