Study Between Cardiovascular Health Index Score And The Incidence Of Hypertension And Pregnancy Induced Hypertension

PurposeTo investigate the relationship between Cardiovascular Health(CVH)Score and the incidence of hypertension and pregnancy induced hypertension.MethodsThis item is based on The Kailuan Study(ChiCTR-TNC-11001489),which is epidemiological studies about Hypertension and it’s risk factors.Kailuan Group provides financial support for worker’s health examination,Once every 2 years.And now,this prospective cohort of 101 510 adults aged 18 to 97 years recruited in 2006–2007(Exam 1)and who were subsequently followed up at2008-2009(Exam 2),2010-2011(Exam 3),and 2012-2013(Exam 4),and 2014-2015(Exam 5)and 2016-2017(Exam 6).First,we prospectively examined the potential association between cumulative CVH(cumCVH)score(except for blood pressure metrics)and incident hypertension.Statistical analyses were performed using commercially available software(SAS 9.3;SAS Institute;Cary,NC).Continuous variables were described as the mean±standard deviation(SD)and were compared by analysis of variance(ANOVA)or the Kruskal–Wallis test.Categorical variables were described as percentages and were compared using the chi-square test.A logistic regression model was used to estimate the risk of hypertension associated with cumCVH metrics.Then,We observed the relationship between the Cardiovascular Health(CVH)Score and Pregnancy induced hypertension(PIH).The main analysis is restricted to those individuals with complete follow-up at all 1-4 examinations and who had no history of Hypertension until Exam 3.Baseline study population were divided into three groups,to investigate the effects between BaselineCVH Score and the Risk of PIH.Using the SPSS software to analyse data.Results 1、Of the 101,510 participants with an age range of 18 to 98 years in this longitudinal community-based Kailuan study,our cohort included those 15,014 participants without hypertension at baseline and who had follow-up examinations 2,4,and 6 years later.CumCVH was calculated as the summed CVH score for each examination multiplied by the time between the 2 examinations(points year).Based on the cumCVH score,the study population was stratified into groups of <44 points,44 to 48 points,49 to 54 points,55 to 59 points,and ≥60 points.Incidence of hypertension ranged from 16.76% in the lowest cumCVH category to 11.52% in the highest cumCVH category.After adjusting for age,sex,education level,income level,high-sensitivity C-reactive protein concentration,uric acid concentration,resting heart rate,parental history of hypertension at baseline,and medication usage before the third follow-up examination,participants in the highest cumCVH category had a significantly reduced risk of incident hypertension compared with those in the lowest cumCVH category(adjusted odds ratio 0.60,95% confidence interval 0.50–0.71).For every increase in category based on the cumCVH score,the risk of hypertension decreased by approximately 2%(odds ratio 0.98,95% confidence interval 0.97–0.98).2、A total of 1150 individuals were under analysis.According to the three percentile of CVH score,the study population was divided into three groups:(CVH score≤9),(10≤CVH score≤11),(CVH score≥12)。In the three groups,the incidence of PIH was 17.6% 、 6.7% 、 5.8%,respectively,P<0.05.After adjusting for age,uric acid concentration ect,participants in the higher CVH score category(group2 and group3)have a significantly reduced risk of incident PIH compared with those in the lowest CVH score category0.37(95%CI:0.19-0.71),0.26(95%CI:0.12-0.57).Conclusions1.A higher cumCVH score is associated with a lower risk of incident hypertension.2.A higher CVH score is associated with a lower risk of incident PIH.